Protein Alignment HOXA10 and HGTX

DIOPT Version :10

• Sequence 1: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 450
• Identity: 92/450 - (20%)
• Similarity: 139/450 - (30%)
• Gaps: 138/450 - (30%)

Human    49 AGGGGGGGYYAH---GGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGY 110
            |...|....:||   ...|....||......:..::.......|..:|..:......|...|||.
  Fly   107 AMSNGFADVHAHAMAAADYQQQLADYHSAAAAAAVYANNNNNNNNNSSNNNNSSPLMLLKAAHGG 171

Human   111 GPSPIDLWLDAPRSCRMEPPDGP--PPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYD 173
            |               ::..|.|  .|||..........|.|..:..|   :..:....||.|..
  Fly   172 G---------------LKDSDSPSTTPPPASSRLHSDSSPSPRYEHNS---SPGVDSAKSYALSQ 218

Human   174 ----SADKCPKVSATAAELAPFPRGPPPDG------------------------CALGTSSGVPV 210
                :.|.| :.|.:|:        |||.|                        .||..::....
  Fly   219 RSSGAEDPC-QTSESAS--------PPPQGQNDYSPENLSSQRAKFQHHHGVNPLALHNANHAGN 274

Human   211 PGYFR--------------------LSQAYGTAKGYGSGGGGAQQLGAGPFPAQP---------- 245
            ||...                    |.......||.|.||..|...|.. :...|
  Fly   275 PGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMKGQGVGGSSASANGLS-YSHSPNSHLISDRGS 338

Human   246 PGRGFDLPPALASGSADAARKERALD---SPPPPTLACG----SGGGSQGDEEAHASSSAAEELS 303
            .|..........:.::..|.....:|   |.|||..:.|    :|.|......|.|::..|:.||
  Fly   339 GGSSSSSSTTTTNTNSQGAPNPHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLS 403

Human   304 PAPSESSKASPEKDSLGN--------------------SKGENAANWLTA-------------KS 335
                 .|:.:|.|...|:                    :..|..:|.::|             |.
  Fly   404 -----QSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKD 463

Human   336 GRKK--RCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKK 393
            |:||  |..::..|...|||.|....||....|.:::.::.:::.|||:||||||.|.:|
  Fly   464 GKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158		15/70 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339		32/167 (19%)
		Homeodomain	337..393	CDD:459649	21/57 (37%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	41/221 (19%)
		Homeodomain	465..523	CDD:459649	21/57 (37%)