DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and ro

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster

Alignment Length:	228	Identity:	61/228 - (26%)
Similarity:	91/228 - (39%)	Gaps:	73/228 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   195 PPP-------DGCALGT---------SSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPA 243
            |||       ||.::.:         :|....|.|    ..||.||.|               |.
  Fly    71 PPPCDTPYHSDGGSVSSPDISISDERTSLAAYPAY----DFYGHAKDY---------------PQ 116

Human   244 QPPGR------GFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEEL 302
            .|..:      ....||.|       ..::.:..||||   |..:||         |::......
  Fly   117 HPSQQHQQHHHHHHHPPQL-------VHQKLSYVSPPP---AIAAGG---------AANPVLPHA 162

Human   303 SPA--PSESSKASPEKDSLGNSKGENAANWLTAKSG--RKKRCPYTKHQTLELEKEFLFNMYLTR 363
            .||  ||:...::.....|...:         .|.|  |::|..::..|||.||.||..|.|::|
  Fly   163 FPAGFPSDPHFSAGFSAFLARRR---------RKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISR 218

Human   364 ERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNR 396
            .||.|::.::.||:.|:||||||||.|.|::.:
  Fly   219 SRRFELAETLRLTETQIKIWFQNRRAKDKRIEK 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		25/127 (20%)
		Homeobox	339..392	CDD:278475	26/52 (50%)
ro	NP_524521.1	Homeobox	196..247	CDD:278475	25/50 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910