DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and Dll

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster

Alignment Length:	215	Identity:	64/215 - (29%)
Similarity:	85/215 - (39%)	Gaps:	64/215 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   198 DG--CALGTSSGVPVPG---YFRLSQAYGTAKGYGS--------GGGGAQQLGAGPFPAQPPGRG 249
            ||  .|...:.|:.:||   :..|.|  ..|.|||.        |..|.|..|   ||:.....|
  Fly    14 DGGNTAASVTPGINIPGKSAFVELQQ--HAAAGYGGIRSTYQHFGPQGGQDSG---FPSPRSALG 73

Human   250 FDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEEL-SPAPSESSKAS 313
            :..||                                     .|.:|.:...| |.||   ..||
  Fly    74 YPFPP-------------------------------------MHQNSYSGYHLGSYAP---PCAS 98

Human   314 PEKDSLG-NSKGENAANWLTAKSGRKKRCPYTKHQTLELE---KEFLFNMYLTRERRLEISRSVH 374
            |.||... :.|.|::...:..| |:|.|.|.|.:.:|:|:   :.|....||....|.|::.|:.
  Fly    99 PPKDDFSISDKCEDSGLRVNGK-GKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLG 162

Human   375 LTDRQVKIWFQNRRMKLKKM 394
            ||..||||||||||.|.|||
  Fly   163 LTQTQVKIWFQNRRSKYKKM 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		28/127 (22%)
		Homeobox	339..392	CDD:278475	24/55 (44%)
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910