DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOXA10 and inv

DIOPT Version :9

Sequence 1:NP_061824.3 Gene:HOXA10 / 3206 HGNCID:5100 Length:410 Species:Homo sapiens
Sequence 2:NP_523699.3 Gene:inv / 36239 FlyBaseID:FBgn0001269 Length:576 Species:Drosophila melanogaster


Alignment Length:387 Identity:92/387 - (23%)
Similarity:123/387 - (31%) Gaps:153/387 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    26 ANSFLVDSLISSGRG----EAGGGGGGAGGGGGGGYYAHGGVYLPPAADLPYGLQSCGLFPTLGG 86
            |..|.:|:::.:..|    :.|...|..|||...|                   .|.|       
  Fly   276 ALKFSIDNILKADFGSRLPKIGALSGNIGGGSVSG-------------------SSTG------- 314

Human    87 KRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPA 151
                 :|..||...|...|             |.||:.      .|.|....|         ..|
  Fly   315 -----SSKNSGNTNGNRSP-------------LKAPKK------SGKPLNLAQ---------SNA 346

Human   152 PQATSCSFAQ---NIKEESSYCLYDSADKCPKVSATAAELAP--FPRGPPPDGCA--------LG 203
            ...:|.||:.   ||...|:    ||.......|.|....||  ..:.|||...|        .|
  Fly   347 AANSSLSFSSSLANICSNSN----DSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASGKSG 407

Human   204 TSSGVPV--PGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALASGSADAARK 266
            ..||.|:  |.:     .|.|                         |..|.|   :||.:..|||
  Fly   408 EDSGTPIVWPAW-----VYCT-------------------------RYSDRP---SSGRSPRARK 439

Human   267 ERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGENAANWL 331
            .:   .|...:.|.|.|||                                  |..||| ||:..
  Fly   440 PK---KPATSSSAAGGGGG----------------------------------GVEKGE-AADGG 466

Human   332 TAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKK 393
            .....::.|..::..|...|:.||..|.|||.:||.::|..:.|.:.|:||||||:|.||||
  Fly   467 GVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKK 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOXA10NP_061824.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..158 13/68 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..339 21/117 (18%)
Homeobox 339..392 CDD:278475 22/52 (42%)
invNP_523699.3 Homeobox 474..527 CDD:278475 22/52 (42%)
Engrail_1_C_sig 529..554 CDD:287495 92/387 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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