DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and nub

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	65/292 - (22%)
Similarity:	95/292 - (32%)	Gaps:	89/292 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   133 PPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPP 197
            |...|||.......|.|..|.:::.|            |..|....|....:..:::.....|.|
  Fly   711 PASSPQQLHHHHHHPLQITPPSSAAS------------LKLSGMLTPSTPTSGTQMSQGTTTPQP 763

Human   198 D---GCALGTSSGVPVP----GYFRLSQAYGTAK------GYGSGGGGAQ--QLGAGPFPAQPPG 247
            .   ..|...::|.|.|    ....|.|...|.|      |:..|..|..  :|....|......
  Fly   764 KTVASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTIS 828

Human   248 RGFD-----------LPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEE 301
            | |:           |.|.|.....||.|..:|            :||                .
  Fly   829 R-FEALNLSFKNMCKLKPLLQKWLDDADRTIQA------------TGG----------------V 864

Human   302 LSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTL---ELEKEFLFNMYLTR 363
            ..||..:::.::||  .:|..              ||||   |..:|.   .|||.||.|...|.
  Fly   865 FDPAALQATVSTPE--IIGRR--------------RKKR---TSIETTIRGALEKAFLANQKPTS 910

Human   364 ERRLEISRSVHLTDRQVKIWFQNRRMKLKKMN 395
            |...:::..:.:....|::||.|||.|.|::|
  Fly   911 EEITQLADRLSMEKEVVRVWFCNRRQKEKRIN 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		24/136 (18%)
		Homeobox	339..392	CDD:278475	19/55 (35%)
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	14/64 (22%)
		Homeobox	886..939	CDD:278475	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910