DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and unc-4

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	77/335 - (22%)
Similarity:	114/335 - (34%)	Gaps:	102/335 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    88 RNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPAP 152
            |:.:.|..|.........|.|..|.||......:...|.| |.:|..|....|
  Fly    47 RSSSTSSNSIPNAHRTNAGQHLLGGSPSSACSTSVSGCGM-PSEGLHPTAALQ------------ 98

Human   153 QATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLS 217
                              ||          |.||:|||               :||.||.:....
  Fly    99 ------------------LY----------AAAAQLAP---------------NGVRVPPWGPFL 120

Human   218 QAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPA----LASGSADAARKERALDSPPP--- 275
            | :|....:|..         |||..:|   .||...|    .::.:|.||.:..|:::...
  Fly   121 Q-FGVPGVFGPN---------GPFLGRP---RFDAASAGGHPNSAAAAAAATQMAAVNASNAFAN 172

Human   276 ----PTLACGSGGGSQGDEEAHASSSAA-----------EELSPA--PSESSKASPEKDSLGNSK 323
                ...|..:...:|....|..:|:.|           :.|.||  |||.|...      |...
  Fly   173 LTGLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAGPPSEGSNED------GGFP 231

Human   324 GENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRR 388
            |:...:...||. |:.|..:...|..|||:.|..:.|.....|..::..:.|.:.:|.:||||||
  Fly   232 GDGDDDSSAAKR-RRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRR 295

Human   389 MKLKKMNREN 398
            .|::|  ||:
  Fly   296 AKVRK--REH 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		30/141 (21%)
		Homeobox	339..392	CDD:278475	17/52 (33%)
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	17/52 (33%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910