DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and Lim1

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	77/354 - (21%)
Similarity:	116/354 - (32%)	Gaps:	133/354 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   126 RMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCS------FAQNIKEESSY--------CLYDSAD 176
            |.|||.|...|                 ...|:      |..|:.|.:.:        ||....|
  Fly    16 RSEPPVGVGDP-----------------CAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTD 63

Human   177 KCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGA-------- 233
            ||     .:.|...:.|.                 .:||   .||| |..|.|.|.|
  Fly    64 KC-----FSRESKLYCRN-----------------DFFR---RYGT-KCSGCGQGIAPSDLVRKP 102

Human   234 ----------------QQLGAGP----------------FPAQPPGRGFDLPPALASGSADAARK 266
                            :||..|.                ...:.|..|.:   :|:.....:|.:
  Fly   103 RDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICKDDYLLGKAPSCGHN---SLSDSLMGSASE 164

Human   267 ERALDSPP---PPTLACG--------SGGGSQGDEEAHASSSAAEELSP-APSESSKASPEKDSL 319
            :...|.||   ...|..|        |.||..|..:....|.:.:..:. ..|:......:.|..
  Fly   165 DDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSMSTDSKNTHDDSDQGSLDGDPDGR 229

Human   320 GNSKGENA----ANWLTAKSGRKKRCPYT--KHQTLELEKEFLFNM--YLTRERRLEISRSVHLT 376
            |:|:.||.    ||      |.|:|.|.|  |.:.||:.|. .||.  ..||..|.::::...|.
  Fly   230 GDSQAENKSPDDAN------GSKRRGPRTTIKAKQLEVLKT-AFNQTPKPTRHIREQLAKETGLP 287

Human   377 DRQVKIWFQNRRMKLKKMNRENRIRELTA 405
            .|.:::||||:|.|      |.|::::|:
  Fly   288 MRVIQVWFQNKRSK------ERRMKQITS 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		33/173 (19%)
		Homeobox	339..392	CDD:278475	20/56 (36%)
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	11/72 (15%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	7/54 (13%)
		COG5576	185..324	CDD:227863	38/139 (27%)
		Homeobox	250..303	CDD:278475	19/59 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910