DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXA10 and Vsx2

DIOPT Version :9

Sequence 1:	NP_061824.3	Gene:	HOXA10 / 3206	HGNCID:	5100	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	37/154 - (24%)
Similarity:	55/154 - (35%)	Gaps:	47/154 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   269 ALDSPPPP-------------------------TLACGSGGGSQGDEEAHASSSAAEELSPAPSE 308
            |:..||||                         :.|.|:|....|              |.||.:
  Fly   158 AVGGPPPPPPMQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPG--------------SLAPKD 208

Human   309 SSKASPEKDSLG-NSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRS 372
            ....|.....:| |||.:.       |..|..|..:|.:|..:||:.|....|.....|..:|..
  Fly   209 FGMESLNGFGVGPNSKKKK-------KKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLK 266

Human   373 VHLTDRQVKIWFQNRRMKLKKMNR 396
            ..|.:.::::||||||.|.:|..:
  Fly   267 TELPEDRIQVWFQNRRAKWRKTEK 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..339		19/95 (20%)
		Homeobox	339..392	CDD:278475	17/52 (33%)
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	17/52 (33%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910