DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment antdh and DHRS11

DIOPT Version :9

Sequence 1:	NP_572695.2	Gene:	antdh / 32058	FlyBaseID:	FBgn0026268	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_077284.2	Gene:	DHRS11 / 79154	HGNCID:	28639	Length:	260	Species:	Homo sapiens

Alignment Length:	255	Identity:	93/255 - (36%)
Similarity:	149/255 - (58%)	Gaps:	15/255 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERWQNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQREL-PAEKRGKLFALYCD 64
            ||||::|:|:|||||.|||:|:|:.||..|:.|||.||.|..::||..|. .|...|.|....||
Human     6 MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70

  Fly    65 VGNESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGYLVDMNPAVMQQVLQTNIMGIVLCTQRAVRS 129
            :.||..:...|..|..:...:|:.:||||..:|..|:..:.:..:.:...|::.:.:||:.|.:|
Human    71 LSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQS 135

  Fly   130 MRERKF-DGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQEFFGLGTRIKITS 193
            |:||.. |||::.|||:.||:.:..:.     .:.|..:|:|||||.||.|||.....|.|:.|.
Human   136 MKERNVDDGHIININSMSGHRVLPLSV-----THFYSATKYAVTALTEGLRQELREAQTHIRATC 195

  Fly   194 VSPGVVDTEIV-------PDSIREAIKD-RMLHSEDIAQGVLYAIATPPHVQVHELIIKP 245
            :|||||:|:..       |:......:. :.|..||:|:.|:|.::||.|:|:.::.::|
Human   196 ISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRP 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
antdh	NP_572695.2	YdfG	1..250	CDD:226674	93/255 (36%)
antdh	NP_572695.2	NADB_Rossmann	1..245	CDD:304358	92/253 (36%)
DHRS11	NP_077284.2	Mgc4172-like_SDR_c	6..256	CDD:187601	93/255 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143372
Domainoid	1	1.000	154	1.000	Domainoid score	I4257
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41560
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3916
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45743
OrthoDB	1	1.010	-	-		D1190834at2759
OrthoFinder	1	1.000	-	-		FOG0000588
OrthoInspector	1	1.000	-	-		otm40752
orthoMCL	1	0.900	-	-		OOG6_100320
Panther	1	1.100	-	-	O	PTHR43115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.810