Protein Alignment Antdh and RDH8

DIOPT Version :10

• Sequence 1: NP_572695.2
• Gene: Antdh / 32058
• FlyBaseID: FBgn0026268
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 76/267 - (28%)
• Similarity: 114/267 - (42%)
• Gaps: 59/267 - (22%)

  Fly     7 RVAVVTGASSGIGSAIAKDL---------VLAGMTVVGLARRVDRVKELQRELPAEKRGK-LFAL 61
            |..:::|.|||||..:|..|         |:|.|..:|       .||.......|..|: |...
Human     6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLG-------KKETLEAAAGEALGQTLTVA 63

  Fly    62 YCDVGNESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGYLVDMNPAVMQQVLQTNIMGIVLCTQRA 126
            ..||.::.||.:....|   .|.:||||||||....|.|..::.|.||.|..||..|.|...:..
Human    64 QLDVCSDESVAQCLSCI---QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAV 125

  Fly   127 VRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQEFFGLGTRIKI 191
            :..|:.|: .||:|:|:|::|      .:||..: :||..||.|:....|....:.  |...|.|
Human   126 LPGMKRRR-QGHIVVISSVMG------LQGVIFN-DVYAASKFALEGFFESLAIQL--LQFNIFI 180

  Fly   192 TSVSPGVVDTEI------------VPDSIREAI---KDRML------------HSEDIAQGVLYA 229
            :.|.||.|.||.            .|.:..|.:   :|..|            :.:|:.|.::..
Human   181 SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNV 245

  Fly   230 IAT--PP 234
            |::  ||
Human   246 ISSTRPP 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antdh	NP_572695.2	Rossmann-fold NAD(P)(+)-binding proteins	1..245	CDD:473865	76/267 (28%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	76/267 (28%)