DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment antdh and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_572695.2	Gene:	antdh / 32058	FlyBaseID:	FBgn0026268	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	241	Identity:	57/241 - (23%)
Similarity:	98/241 - (40%)	Gaps:	35/241 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNRVAVVTGASSGIGSAIA-------KDLVLAGMTVVGLARRVDRVKELQRELPAEKRGKLFALY 62
            |....::|||::|:|..:|       ..|||...|...|.:.|...::|...       |:|.:.
Human    75 QGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAP-------KVFYIA 132

  Fly    63 CDVGNESSVNEAFDWIIQKLGAIDVLVNN------AGTLQPGYLVDMNPAVMQQVLQTNIMGIVL 121
            .|:.:..:......:.:.|||.:|.||.|      |||..      .:|...:.::|.|.:..|.
Human   133 ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRA------RSPQATRWLMQVNFVSYVQ 191

  Fly   122 CTQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQEFFGLG 186
            .|.||:.|:.:.|  |.:|:::|:||.   ..|....|    |..:|.|:.......|:|.....
Human   192 LTSRALPSLTDSK--GSLVVVSSLLGR---VPTSFSTP----YSAAKFALDGFFGSLRRELDVQD 247

  Fly   187 TRIKITSVSPGVVDTEIVPDSIREAIKDRMLHSEDIAQGVLYAIAT 232
            ..:.||....|:.|.....:::|...:.:.......|..|:...||
Human   248 VNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGAT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
antdh	NP_572695.2	YdfG	1..250	CDD:226674	57/241 (24%)
antdh	NP_572695.2	NADB_Rossmann	1..245	CDD:304358	57/241 (24%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	57/241 (24%)
		PRK08251	78..302	CDD:181324	56/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810