Protein Alignment Antdh and HSD11B1

DIOPT Version :10

• Sequence 1: NP_572695.2
• Gene: Antdh / 32058
• FlyBaseID: FBgn0026268
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_005516.1
• Gene: HSD11B1 / 3290
• HGNCID: 5208
• Length: 292
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 60/242 - (24%)
• Similarity: 103/242 - (42%)
• Gaps: 36/242 - (14%)

  Fly     2 ERWQNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAE--KRGKLFALYCD 64
            |..|.:..:|||||.|||..:|..|...|..||..||.    ||..:::.:.  :.|...|.|.
Human    30 EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS----KETLQKVVSHCLELGAASAHYI- 89

  Fly    65 VGNESSVNEAFDWIIQK---LGAIDVLVNNAGTLQPGYLVDMNPAVMQQVLQTNIMGIVLCTQRA 126
            .|....:..|..::.|.   :|.:|:|:.|..|.....|...:...:::.::.|.:..|:.|..|
Human    90 AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAA 154

  Fly   127 VRSMRERKFDGHVVLINSILGHKTMTATEGVA-PDVNVYPPSKHAVTALAEGYRQEFFGLGTRIK 190
            :..:::.  :|.:|:::|:.|.        || |.|..|..||.|:.......|:|:......:.
Human   155 LPMLKQS--NGSIVVVSSLAGK--------VAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVS 209

  Fly   191 ITSVSPGVVDTEIVPDSIR---------------EAIKDRMLHSEDI 222
            ||....|::|||....::.               |.||...|..|::
Human   210 ITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antdh	NP_572695.2	Rossmann-fold NAD(P)(+)-binding proteins	1..245	CDD:473865	60/242 (25%)
HSD11B1	NP_005516.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	59/240 (25%)