Protein Alignment Antdh and DHRS1

DIOPT Version :10

• Sequence 1: NP_572695.2
• Gene: Antdh / 32058
• FlyBaseID: FBgn0026268
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_612461.1
• Gene: DHRS1 / 115817
• HGNCID: 16445
• Length: 313
• Species: Homo sapiens
• Alignment Length: 254
• Identity: 71/254 - (27%)
• Similarity: 111/254 - (43%)
• Gaps: 40/254 - (15%)

  Fly     7 RVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAEKRGKLFALYCDVGNESSV 71
            :|.||||||.|||..||..|..||.||....|.:|.::.:.:|..: ..|:...:.||...||.|
Human     8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQS-LGGQCVPVVCDSSQESEV 71

  Fly    72 NEAFDWI-IQKLGAIDVLVNNAGTLQPGYLVDMN---------PAVM-QQVLQTNIMGIVLCTQR 125
            ...|:.: .::.|.:|||||||   ..|....:|         ||.| ..:....:.|...|:..
Human    72 RSLFEQVDREQQGRLDVLVNNA---YAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVY 133

  Fly   126 AVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNV-YPPSKHAVTALAEGYRQEFFGLGTRI 189
            ..|.|.... .|.:|:|:|....:.|         .|| |...|.|...||.....|....|  :
Human   134 GARLMVPAG-QGLIVVISSPGSLQYM---------FNVPYGVGKAACDKLAADCAHELRRHG--V 186

  Fly   190 KITSVSPGVVDTEIVPDSI--REAIKDRML----------HSEDIAQGVLYAIATPPHV 236
            ...|:.||:|.||::.:.:  .|.::|.:|          .:.:::...:.|:||.|::
Human   187 SCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALATDPNI 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Antdh	NP_572695.2	Rossmann-fold NAD(P)(+)-binding proteins	1..245	CDD:473865	71/254 (28%)
DHRS1	NP_612461.1	DHRS1-like_SDR_c	5..271	CDD:187664	71/254 (28%)
		Required for ER localization. /evidence=ECO:0000269|PubMed:30031147	235..313		4/11 (36%)