DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and Dync1li2

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_112288.1	Gene:	Dync1li2 / 81655	RGDID:	621130	Length:	497	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	220/483 - (45%)
Similarity:	298/483 - (61%)	Gaps:	24/483 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DAAAEKE---NLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLIAKLQGVEDPKKGSGLEY 83
            |..:|:|   :|||:||:||.|:..:||||.|::||.|::.:|||||:.||||.|..|||.||||
  Rat    24 DLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEY 88

  Fly    84 AYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILTVSMTQPWGWLEQLNHWI 148
            .|:.|.||.|||.||..||:||||..|..||.:|::..:...||||....|::||..:|.|..|.
  Rat    89 LYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWA 153

  Fly   149 KVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTMRNNSIDEDDL-LPLTED 212
            .||.:|||.:::..:|.....::....:|.|.|..:... |||.:|....:..|||:: |||.::
  Rat   154 SVLREHIDKMKIPPEEMRDLERKFMKDFQDYIEPEEGCQ-GSPQRRGPLTSGSDEDNVALPLGDN 217

  Fly   213 ALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCLRHGTSLFYTSVKEDKNCDV 277
            .|..|||:.::||.||.|.::.||||::|||||.||||..:|.|||::|.:|.||||||:||.|:
  Rat   218 VLTHNLGIPVLVVCTKCDAVSILEKEHDYRDEHLDFIQAHLRGFCLQYGAALIYTSVKEEKNLDL 282

  Fly   278 LYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGVKAENPYTDIIKSPPTRK 342
            ||||:.|:.||..|..||||||||||.||||||:.|||:||:||...||.|:.|.|.|..||.||
  Rat   283 LYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRK 347

  Fly   343 AVSNREAEVQTEDEQAFLARQQEILKQGDQVRGESPLRSQGVGSNKSGP-RTPGTTGQSSPKKID 406
            .|.::  |:..||||.||.:|||...:|.   ..|| |:||.|...|.| .:|||    |.||.|
  Rat   348 LVHDK--ELAAEDEQVFLMKQQESPARGP---SGSP-RTQGRGGPASVPSASPGT----SVKKPD 402

  Fly   407 PKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGPGG-------AGNPAGPGRTANGTDAVMTPEK 464
            |.: .....:|||||:||||||.||:||||:...||       :|....|....:.|:......:
  Rat   403 PNI-KNNAASEGVLASFFNSLLSKKTGSPGSPSAGGVQSTAKKSGTEGEPQSFRSLTEQCCQTGQ 466

  Fly   465 LAVRTDAAAELDRLSRSVKKEIDMSQSE 492
            ..|.::...||||::|.....:..|.:|
  Rat   467 KTVLSNVQEELDRMTRKPDSMVTNSSTE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	219/480 (46%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	20/35 (57%)
Dync1li2	NP_112288.1	DLIC	30..493	CDD:283447	217/474 (46%)
		AAA	46..>100	CDD:99707	30/53 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..206		4/19 (21%)
		P-loop_NTPase	218..>294	CDD:304359	43/75 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..408		20/50 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..461		12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..497		7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336555
Domainoid	1	1.000	400	1.000	Domainoid score	I714
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4474
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1860
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm44876
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	O	PTHR12688
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810