DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and dync1li2

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001017669.2	Gene:	dync1li2 / 573266	ZFINID:	ZDB-GENE-050417-156	Length:	500	Species:	Danio rerio

Alignment Length:	482	Identity:	231/482 - (47%)
Similarity:	309/482 - (64%)	Gaps:	23/482 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALTSSFTMKKKDAAAEKENLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLIAKLQGVEDP 75
            |:.:..||:..:...|.:||||:||:||.|:.|:||||.|:||:.|::.:|||||::||||.|..
Zfish    12 AVGTGDTMENSNEDDEGQNLWSSILSEVSTRSSSKLPSGKNVLLFGEDGSGKTTLMSKLQGAEHN 76

  Fly    76 KKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILTVSMTQPWGW 140
            |||.||||.|::|:||..||:||..||:||||..|..||.:|:...:...:|.:..|.|::||..
Zfish    77 KKGRGLEYLYLNVQDEDIDDLTRCSVWILDGDLYHKGLLKFAVTAESLKDSLAVFVVDMSRPWTI 141

  Fly   141 LEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTMRNNSIDEDD 205
            :|.|..|..||.:|:|.|::..:|.....||:...:|.|.| .::..||||.:|.......||..
Zfish   142 MESLQKWTSVLREHVDKLRIPPEEMREMEQRMVKAFQEYVE-PEEATPGSPQRRAPAAAGEDESV 205

  Fly   206 LLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCLRHGTSLFYTSVK 270
            ||||.::.|..|||:.:::|.||.|.:..||||::|::|||||||..||.|||::|..|.|||||
Zfish   206 LLPLADNVLTHNLGIPMLIVCTKCDAVNVLEKEHDYKEEHFDFIQSHIRRFCLQYGAGLIYTSVK 270

  Fly   271 EDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGVKAENPYTDII 335
            |:||.|:||||:.|:||...|.:||||||||||.||:|||:.|||.||:||...|:.|:|:.|.|
Zfish   271 EEKNLDLLYKYMVHKIYDFQFSSPALVVEKDAVFIPSGWDNDKKICILHENFTTVRPEDPFEDFI 335

  Fly   336 KSPPTRKAVSNREAEVQTEDEQAFLARQQEIL-KQ-GDQVRG-ESPLRSQGVGSNKSGPRTPGTT 397
            ..||.||.|.::  |:..||||.||.:||.:| || ....|| |||.|:.. ||    ||..|.|
Zfish   336 TKPPVRKLVHDK--EISAEDEQVFLMKQQSLLAKQPATPTRGTESPARTAS-GS----PRPTGRT 393

  Fly   398 GQS-----SP----KKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGPGGAGNPAGPGRTA 453
            |.:     ||    ||.||.:..|... ||||||||||||.||:|.||:.|..|||..||.|...
Zfish   394 GPTNVASVSPMTAVKKPDPNMKGAAAN-EGVLANFFNSLLSKKTGVPGSPGTPGAGAGAGTGTGV 457

  Fly   454 NGTDAVMTPEKLAVRTDAAAELDRLSR 480
            .|: |..|.:|..: ||..|||||::|
Zfish   458 QGS-AKKTGQKPGL-TDVQAELDRMTR 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	228/468 (49%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	21/35 (60%)
dync1li2	NP_001017669.2	DLIC	26..493	CDD:283447	228/468 (49%)
		P-loop_NTPase	46..>101	CDD:304359	33/54 (61%)
		Ras_like_GTPase	<219..284	CDD:206648	37/64 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575701
Domainoid	1	1.000	410	1.000	Domainoid score	I659
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4474
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1815
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm26070
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	O	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840