DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and dync1li1

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001095898.1	Gene:	dync1li1 / 556103	ZFINID:	ZDB-GENE-030131-4108	Length:	501	Species:	Danio rerio

Alignment Length:	501	Identity:	230/501 - (45%)
Similarity:	308/501 - (61%)	Gaps:	37/501 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MNSGTQTNALTSSFTMKKKDAAAEKENLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLIA 67
            ::..|..|..||.....:::   :.:||||:||:||.|:..:||||.|:|:|:|:..:|||||:|
Zfish    10 LSVSTNVNNSTSESQNPEEE---DGQNLWSSILSEVSTRSRSKLPSGKNVVVMGEVGSGKTTLVA 71

  Fly    68 KLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILTV 132
            ||||||:..||.||||.|.:|.|:..||.:|...||||||..|..|..:|::..|...:|::..|
Zfish    72 KLQGVEEYMKGRGLEYLYFNVHDDDIDDQSRCNAWVLDGDLYHKGLQKFAISLENLEDSLILFVV 136

  Fly   133 SMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTMR 197
            .:::||..|:.|..|..|:...:|.|::..:.......|||..:|.|.|.|.||| ..|.:   |
Zfish   137 DLSRPWLALDSLQKWGSVVRDFVDKLRVPPETMRELEHRLTKQFQEYVEPGSDLD-AVPQR---R 197

  Fly   198 NNSIDEDD-LLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCLRHG 261
            |...||:. ||||.|:.|..||||.||||.||.|.::|||||::|:|||.||||..||.|||::|
Zfish   198 NPESDEESVLLPLGENTLTHNLGLPIVVVCTKCDAISTLEKEHDYKDEHLDFIQSHIRRFCLQYG 262

  Fly   262 TSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGVK 326
            .:|.|||:||:||.|:|||||.||:||.||.:||.|||||:|.||:|||:.|||:||:||...||
Zfish   263 AALLYTSMKENKNLDLLYKYLVHRLYGFPFNSPAQVVEKDSVFIPSGWDNEKKIAILHENFQMVK 327

  Fly   327 AENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEILKQGDQVRGESPLRSQGVGSNKSGP 391
            ||:.:.|:|..||.||.|  .|.|||.||:|.||.:.|.:|.:...|....|:..    :|::..
Zfish   328 AEDSFEDVIVKPPVRKFV--HEKEVQAEDDQVFLVKLQSLLSKQPPVTAGRPVDP----TNRAPT 386

  Fly   392 RTPGTTG-------------QSSPKKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGPGGA 443
            .:|.||.             ||..|||||.:..... :||||||||||||.||:||||.|
Zfish   387 GSPRTTNRSAAANVANVMPMQSGTKKIDPNMKGGQT-SEGVLANFFNSLLTKKAGSPGPG----- 445

  Fly   444 GNPAGPGRTANGTDAVMTPEKLAVRTDAAAELDRLSRSVKKEIDMS 489
            |.|||.|....|| ...:..||.: ||..|||||:|.  |.::|.|
Zfish   446 GQPAGGGSNTPGT-VRKSGSKLGL-TDVQAELDRISN--KSDLDSS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	226/479 (47%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	21/35 (60%)
dync1li1	NP_001095898.1	DLIC	29..495	CDD:283447	226/482 (47%)
		AAA_18	56..178	CDD:289979	49/121 (40%)
		P-loop_NTPase	<217..287	CDD:304359	45/69 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575700
Domainoid	1	1.000	410	1.000	Domainoid score	I659
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1815
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm26070
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	LDO	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940