DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and DYNC1LI1

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_057225.2	Gene:	DYNC1LI1 / 51143	HGNCID:	18745	Length:	523	Species:	Homo sapiens

Alignment Length:	516	Identity:	237/516 - (45%)
Similarity:	317/516 - (61%)	Gaps:	63/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GTQTNALTSSFT---------MKKKDAAA----EKENLWSAILNEVQTQGSTKLPSNKSVLVLGD 57
            |:....|:|::|         .....|||    :.:||||.||:||.|:..:|||:.|:||:||:
Human    11 GSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGE 75

  Fly    58 NATGKTTLIAKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETN 122
            :..|||:||.|:||:|:.|||.||||.|::|.||.|||.||..||:||||..|..||.::|:..:
Human    76 DGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVS 140

  Fly   123 YAHTLVILTVSMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLD 187
            ...|||:|.|.|::||..|:.|..|..|:.:|:|.|::..:|.:...|:|...:|.|.|.|:|.
Human   141 LKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDF- 204

  Fly   188 PGSPVKRTMRNNSIDEDD--LLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQ 250
            |.||.:|...:.. |:||  :|||..|.|..|||:.::||.||.|.::.||||::||||||||||
Human   205 PASPQRRNTASQE-DKDDSVVLPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFIQ 268

  Fly   251 QWIRNFCLRHGTSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKI 315
            ..||.|||::|.:|.||||||:||.|::|||:..::||.|::.||:|||||||.||||||:.|||
Human   269 SHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKI 333

  Fly   316 SILYENMHGVKAENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEIL-KQGDQVRGE--- 376
            .||:||...:|||:.:.|||..||.||.|  .|.|:..||:|.||.:.|.:| ||.....|.
Human   334 GILHENFQTLKAEDNFEDIITKPPVRKFV--HEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVD 396

  Fly   377 -SPLRSQGVGSNKSGPRTPGTTGQS-----SP-----KKIDPKLTPATPGAEGVLANFFNSLLHK 430
             || |..| ||    ||||..:..|     ||     |||||.: .|...:||||||||||||.|
Human   397 ASP-RVPG-GS----PRTPNRSVSSNVASVSPIPAGSKKIDPNM-KAGATSEGVLANFFNSLLSK 454

  Fly   431 KSGSPGTGGPG-GAGNPAG----------PGRTANGTDAVMTPEKLAVRTDAAAELDRLSR 480
            |:|||  |||| ..|:|||          |....:|...|:         |..|||||::|
Human   455 KTGSP--GGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVL---------DVHAELDRITR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	231/488 (47%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	19/35 (54%)
DYNC1LI1	NP_057225.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		4/13 (31%)
		DLIC	43..517	CDD:368612	230/484 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..434		19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..523		21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142863
Domainoid	1	1.000	401	1.000	Domainoid score	I736
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1933
Isobase	1	0.950	-	0	Normalized mean entropy	S4581
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm40736
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	LDO	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.790