DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and Dync1li1

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_665715.2	Gene:	Dync1li1 / 252902	RGDID:	71072	Length:	523	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	236/500 - (47%)
Similarity:	311/500 - (62%)	Gaps:	42/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGTQTNALTSSFTMKKKDAAAEKE---NLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLI 66
            ||...|.|.|.   ....||.:.|   ||||.||:||.|:..:|||:.|:||:||::..|||:||
  Rat    23 SGPLANELASG---SGGPAAGDDEDGQNLWSCILSEVSTRSRSKLPTGKNVLLLGEDGAGKTSLI 84

  Fly    67 AKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILT 131
            .::||:|:.|||.||||.|::|.||.|||.||..||:||||..|..||.::|:..:...|||:|.
  Rat    85 RRIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLV 149

  Fly   132 VSMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKR-T 195
            |.|::||..|:.|..|..|:.:|:|.|::..:|.:...|:|...:|.|.|.|:|. |.||.:| |
  Rat   150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDF-PASPQRRAT 213

  Fly   196 MRNNSIDEDDLLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCLRH 260
            ......|:..:|||..|.|..||||.::||.||.|.::.||||::||||||||||..||.|||::
  Rat   214 AAQEDRDDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQY 278

  Fly   261 GTSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGV 325
            |.:|.||||||:||.|::|||:..::||.|::.||:|||||||.||||||:.|||.||:||...:
  Rat   279 GAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTL 343

  Fly   326 KAENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEIL-KQGDQVRGE----SPLRSQGVG 385
            |.|:.:.|||..||.||.|  .|.|:..||:|.||.:.|.:| ||.....|.    || |..| |
  Rat   344 KIEDNFEDIITKPPVRKFV--HEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASP-RVPG-G 404

  Fly   386 SNKSGPRTPGTTGQS-----SP-----KKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGP 440
            |    ||||..:..|     ||     |||||.: .|...:||||||||||||.||:|||  |||
  Rat   405 S----PRTPNRSVSSNVASVSPIPAGSKKIDPNM-KAGATSEGVLANFFNSLLSKKTGSP--GGP 462

  Fly   441 GGAGNPAGPGRTANGTDAVMTPE-----KLAVRTDAAAELDRLSR 480
            |..|:|.|   .|.|....:.|.     :..|.:|..|||||::|
  Rat   463 GVGGSPGG---GAAGASTSLPPSAKKSGQKPVLSDVHAELDRITR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	228/479 (48%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	18/35 (51%)
Dync1li1	NP_665715.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		8/24 (33%)
		DLIC	43..517	CDD:368612	228/476 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..434		19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..523		20/52 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336554
Domainoid	1	1.000	400	1.000	Domainoid score	I714
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1860
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm44876
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	LDO	PTHR12688
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810