DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlic and Dync1li1

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_666341.1	Gene:	Dync1li1 / 235661	MGIID:	2135610	Length:	523	Species:	Mus musculus

Alignment Length:	519	Identity:	241/519 - (46%)
Similarity:	318/519 - (61%)	Gaps:	53/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGTQTNALTSSFTMKKKDAAAEKE---NLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLI 66
            ||...|.|.|.   ....||.:.|   ||||.||:||.|:..:|||:.|:||:||::..|||:||
Mouse    23 SGPLANELASG---SGGPAAGDDEDGQNLWSCILSEVSTRSRSKLPTGKNVLLLGEDGAGKTSLI 84

  Fly    67 AKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILT 131
            .::||:|:.|||.||||.|::|.||.|||.||..||:||||..|..||.::|:..:...|||:|.
Mouse    85 RRIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLV 149

  Fly   132 VSMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTM 196
            |.|::||..|:.|..|..|:.:|:|.|::..:|.:...|:|...:|.|.|.|:|. |.||.:||.
Mouse   150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDF-PASPQRRTT 213

  Fly   197 -----RNNSIDEDDLLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNF 256
                 |.:|:    :|||..|.|..||||.::||.||.|.::.||||::||||||||||..||.|
Mouse   214 GAQEDRGDSV----VLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKF 274

  Fly   257 CLRHGTSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYEN 321
            ||::|.:|.||||||:||.|::|||:..::||.|::.||:|||||||.||||||:.|||.||:||
Mouse   275 CLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHEN 339

  Fly   322 MHGVKAENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEIL-KQGDQVRGE----SPLRS 381
            ...:|.|:.:.|||..||.||.|  .|.|:..||:|.||.:.|.:| ||.....|.    || |.
Mouse   340 FQTLKVEDNFEDIITKPPVRKFV--HEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASP-RV 401

  Fly   382 QGVGSNKSGPRTPGTTGQS-----SP-----KKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPG 436
            .| ||    ||||..:..|     ||     |||||.: .|...:||||||||||||.||:|||
Mouse   402 PG-GS----PRTPNRSVSSNVASVSPIPAGSKKIDPNM-KAGATSEGVLANFFNSLLSKKTGSP- 459

  Fly   437 TGGPGGAGNPAGPGRTANGTDAVMTPE-----KLAVRTDAAAELDRLSR---SVKKEIDMSQSE 492
             ||||..|:|.|   .|.|....:.|.     :..|.:|..|||||::|   ||......|.:|
Mouse   460 -GGPGVGGSPGG---GAAGASPSLPPSAKKSGQKPVLSDVHAELDRITRKPASVSPTTPTSPTE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	234/499 (47%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	18/35 (51%)
Dync1li1	NP_666341.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		1/1 (100%)
		DLIC	43..519	CDD:283447	233/494 (47%)
		P-loop_NTPase	70..302	CDD:304359	115/236 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..219		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..434		19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..523		25/68 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832985
Domainoid	1	1.000	399	1.000	Domainoid score	I740
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1917
Isobase	1	0.950	-	0	Normalized mean entropy	S4581
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm42810
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	LDO	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.790