DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlic and DYNC1LI2

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_006132.1	Gene:	DYNC1LI2 / 1783	HGNCID:	2966	Length:	492	Species:	Homo sapiens

Alignment Length:	486	Identity:	219/486 - (45%)
Similarity:	299/486 - (61%)	Gaps:	35/486 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DAAAEKE---NLWSAILNEVQTQGSTKLPSNKSVLVLGDNATGKTTLIAKLQGVEDPKKGSGLEY 83
            |..:|:|   :|||:||:||.|:..:||||.|::||.|::.:|||||:.||||.|..|||.||||
Human    24 DLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEY 88

  Fly    84 AYIDVKDEYRDDMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILTVSMTQPWGWLEQLNHWI 148
            .|:.|.||.|||.||..||:||||..|..||.:|::..:...||||....|::||..:|.|..|.
Human    89 LYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWA 153

  Fly   149 KVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTMRNNSIDEDDL-LPLTED 212
            .||.:|||.:::..::.....::....:|.|.|..:... |||.:|....:..||::: |||.::
Human   154 SVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQ-GSPQRRGPLTSGSDEENVALPLGDN 217

  Fly   213 ALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCLRHGTSLFYTSVKEDKNCDV 277
            .|..|||:.::||.||.|.::.||||::|||||.||||..:|.|||::|.:|.||||||:||.|:
Human   218 VLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDL 282

  Fly   278 LYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGVKAENPYTDIIKSPPTRK 342
            ||||:.|:.||..|.|||||||||||.||||||:.|||:||:||...||.|:.|.|.|..||.||
Human   283 LYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRK 347

  Fly   343 AVSNREAEVQTEDEQAFLARQQEILKQGDQV---RGESPL-------RSQGVGSNKSGP-RTPGT 396
            .|.::  |:..||||.||.:||.:|.:....   ..|||.       |:||.|...|.| .:|||
Human   348 LVHDK--ELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGT 410

  Fly   397 TGQSSPKKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGPGGAGNPAGPGRTANGTDAVMT 461
                |.||.||.: .....:|||||:||||||.||:||||:.|.||..:.|    ..:|...|:
Human   411 ----SVKKPDPNI-KNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTA----KKSGQKTVL- 465

  Fly   462 PEKLAVRTDAAAELDRLSRSVKKEIDMSQSE 492
                   ::...||||::|.....:..|.:|
Human   466 -------SNVQEELDRMTRKPDSMVTNSSTE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	218/483 (45%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	20/35 (57%)
DYNC1LI2	NP_006132.1	DLIC	30..488	CDD:368612	216/477 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..206		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..423		17/56 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..492		20/65 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142862
Domainoid	1	1.000	401	1.000	Domainoid score	I736
eggNOG	1	0.900	-	-		E1_KOG3905
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4474
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		otm40736
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	O	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840