DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlic and dli-1

DIOPT Version :9

Sequence 1:	NP_572694.1	Gene:	Dlic / 32057	FlyBaseID:	FBgn0030276	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_502518.2	Gene:	dli-1 / 178260	WormBaseID:	WBGene00001007	Length:	443	Species:	Caenorhabditis elegans

Alignment Length:	489	Identity:	144/489 - (29%)
Similarity:	220/489 - (44%)	Gaps:	114/489 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EKENLWSAILNEVQT---QGSTKLPSNKSVLVLGDNATGKTTLIAKLQGVE---DPKKGSGLEYA 84
            |:..:|..:|...:|   ||||       |:|||||.:||::|:::|...:   .||  |.|.|.
Worm    27 EEVGIWRELLASKKTNTNQGST-------VIVLGDNRSGKSSLLSRLDKSDRTVKPK--SLLGYR 82

  Fly    85 YIDVKDEYRD-----------------DMTRLGVWVLDGDPGHTNLLHYALNETNYAHTLVILTV 132
            .:.|:::.||                 ::.::.||.|||:....:||.:||..|. |..:.|||.
Worm    83 VLHVQNDARDASYAYQLGTAGANLNPSELLQIPVWSLDGNAACASLLKHALPATP-AEAIFILTA 146

  Fly   133 SMTQPWGWLEQLNHWIKVLGQHIDSLQLDAKEKEAARQRLTTTWQSYCEVGDDLDPGSPVKRTMR 197
            |:..| ..:..|..|..|..:.... ....::.:|.|.:....||.|.:         ||:..|.
Worm   147 SIDNP-NLIHSLKRWANVCTEQAQK-HFTKEDLKAGRSQQEKMWQEYVD---------PVQSQMS 200

  Fly   198 NNSI----DEDDLLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRNFCL 258
            .:.:    ||.:||||.:..|..|.|:..:||:||:|.:  |.|  |:.|..|..|...:|.|||
Worm   201 TSVVGSFADEHNLLPLDQGTLTENCGVTFMVVITKSDLV--LGK--EFTDAQFAKISIQLRKFCL 261

  Fly   259 RHGTSLFYTSVKEDKNCDVLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMH 323
            ..|.:|.:||.||.||..:|.||:.||.:|..|.:.|.|:|::::.:|||||..|||.|:.|::.
Worm   262 SLGATLVFTSAKETKNIQLLQKYIVHRSFGTAFTSAAQVIERESIFVPAGWDGEKKIDIIRESIP 326

  Fly   324 GV-KAENPYTDIIKSPPTRKAVSNREAEVQTEDEQAFLARQQEILKQGDQVRGESPLRSQGVGSN 387
            .| .|..|..|  |..|..|     |..::.|::||||.:..:||..........|...|...::
Worm   327 DVDSALEPTRD--KLRPVAK-----EQLIEAEEDQAFLKKLMDILATSTTTAAPKPRTMQEEPTD 384

  Fly   388 KSGPRTPGTTGQSSPKKIDPKLTPATPGAEGVLANFFNSLLHKKSGSPGTGGPGGAGNPAGPGRT 452
            |..|                            |||||::||:|...|
Worm   385 KDSP----------------------------LANFFSNLLNKDKPS------------------ 403

  Fly   453 ANGTDAVMTPEKLAVRTDAA---AELDRLSRSVK 483
                 .|.:|..::...|||   |:||||.:|.:
Worm   404 -----KVSSPSTVSQPMDAAATQAQLDRLLKSAQ 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlic	NP_572694.1	DLIC	25..493	CDD:283447	144/489 (29%)
Dlic	NP_572694.1	ABC_ATPase	43..>79	CDD:213179	14/38 (37%)
dli-1	NP_502518.2	DLIC	26..433	CDD:283447	144/489 (29%)
dli-1	NP_502518.2	P-loop_NTPase	220..>285	CDD:304359	28/68 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157368
Domainoid	1	1.000	154	1.000	Domainoid score	I2612
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4474
Inparanoid	1	1.050	164	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54892
OrthoDB	1	1.010	-	-		D1299592at2759
OrthoFinder	1	1.000	-	-		FOG0003091
OrthoInspector	1	1.000	-	-		oto20007
orthoMCL	1	0.900	-	-		OOG6_102941
Panther	1	1.100	-	-	LDO	PTHR12688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3151
SonicParanoid	1	1.000	-	-		X2062
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940