DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lint-1 and chd3

DIOPT Version :9

Sequence 1:	NP_001285113.1	Gene:	Lint-1 / 32055	FlyBaseID:	FBgn0030274	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	XP_009301392.1	Gene:	chd3 / 568230	ZFINID:	ZDB-GENE-121031-4	Length:	2101	Species:	Danio rerio

Alignment Length:	654	Identity:	118/654 - (18%)
Similarity:	207/654 - (31%)	Gaps:	231/654 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QRSLRDFLKVHALVSEVFDEQADA-------------DPVQMRRILDELEEEVYEINAEQQFLLL 86
            ::.|.|.||..  ..|:|.::.:|             |...:.|:||..::...:.:.:
Zfish  1233 KQELDDILKFG--TEELFKDEIEAGDNKDDDMSVIHYDNAAIERLLDRSQDATDDSDMQ------ 1289

  Fly    87 RLNDSLQEFSV---KLKENNIMFLPDIAHEYVSAQVVPLIVDPNYKIMPQSVMARDTEEMLIRKH 148
            .:|:.|..|.|   .:||::  .:.:|..|.:..:.   .|||:|            .|.|:|.|
Zfish  1290 NMNEYLSSFKVAQYTVKEDD--KIEEIEREIIKQEE---NVDPDY------------WEKLLRHH 1337

  Fly   149 FLLSQDDDSGMPPLKLSELDENIPLMLAPPVRGLGQQIA-------AVKPEPEWLQGDEATVSVP 206
            :...|:|           |..|:         |.|:::.       |.:.:.||    .|.:|
Zfish  1338 YEQQQED-----------LARNL---------GKGKRVRKQVNYNDAAQEDQEW----HADIS-- 1376

  Fly   207 PPPPQSKSKLMKGS------LDSTP----AKRENISRSSPPPLAPITQTVVAELSQVPPSPQAES 261
                .::|:...||      .|..|    ..|..:......||.|:...|...:..:..:.:...
Zfish  1377 ----DNQSEYSVGSEEEDEDFDERPEGRRQSRRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRK 1437

  Fly   262 PPVN----FHVVAQSRKNLQQALRRAR-KTKQQPRLFDDEEDLEITSLQNDRNKNRTSDGK---- 317
            ..:|    :.:.||...:.|..:|..| |::::.:.:        .||.........:||.
Zfish  1438 AFLNAIMRWGMPAQDAFSSQWLVRDLRGKSEKEFKAY--------VSLFMRHLCEPVADGSETFA 1494

  Fly   318 -GTP-------PSLEPTNAAANQAAKKTIPQM-------SSQGMAKNNTAKSKNTCRKSSP---- 363
             |.|       |.|  |........||.:.:.       |...:....|..||.:.|.|||
Zfish  1495 DGVPREGLCRQPVL--TRIGVMSLVKKKVQEFEHINGKWSMPELKPEITVDSKKSSRASSPTIKT 1557

  Fly   364 -TPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPEEYGQETFLGLFEL 427
             |||      |.:|.:.:...|.........:...||.:...:..||.|:||.
Zfish  1558 DTPT------PELSCNNTPCTSKPATPSPPDKTEKSAKEAEKDEAESLTEPER------------ 1604

  Fly   428 YSPEVLKKLSQRHSKRKRRTVQNASGVDFHYGQQLNAVDALVMGVRGQK---------------- 476
                      :|..::.:...:..|.....:|:        ..|..|:|
Zfish  1605 ----------EREKEKAKEAKEGESVESTEHGE--------ATGNEGEKDPITSEKSQTSESPAA 1651

  Fly   477 ------KTKEKSEFLLSPTEKRLQANSKRTYTRKSKSPDEISEKSSAGGGSGASGTASSSACQHK 535
                  ||||..:...||.:::.:...:.....|.|.|.  :||.|           .|.:.:.:
Zfish  1652 AASDDSKTKENPDISQSPPKEKNEKEKQEEEEGKEKEPS--TEKPS-----------DSPSVKEE 1703

  Fly   536 DGGASKCRKCRECRECKRRVETEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPP--CLREKD 598
            ...|.|..|..:..|.|.:.|..:                               ||  ...:||
Zfish  1704 SKEALKGDKKEKAGEEKEKTEASS-------------------------------PPSETTEKKD 1737

  Fly   599 KLEK 602
            ||::
Zfish  1738 KLDQ 1741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lint-1	NP_001285113.1	PHD	548..593	CDD:214584	5/46 (11%)
chd3	XP_009301392.1	CHDNT	181..233	CDD:285335
		PHD1_CHD_II	385..427	CDD:277006
		PHD2_CHD_II	470..512	CDD:277007
		Chromo	647..>681	CDD:278797
		SNF2_N	750..1046	CDD:278600
		DEXDc	767..925	CDD:238005
		Helicase_C	1070..1185	CDD:278689
		DUF1087	<1324..1368	CDD:283996	15/75 (20%)
		DUF1086	1397..1536	CDD:283992	25/148 (17%)
		CHDCT2	1809..1980	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900