DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lint-1 and tou

DIOPT Version :9

Sequence 1:	NP_001285113.1	Gene:	Lint-1 / 32055	FlyBaseID:	FBgn0030274	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	144/783 - (18%)
Similarity:	264/783 - (33%)	Gaps:	261/783 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KYYVLPLE--------LKNDIIYCQRSL--RDFL------KVHALVS-----------EVFDEQA 56
            :||.:|::        |.|:.|:....|  :..|      |.|.:.|           |..|::.
  Fly  2003 QYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEE 2067

  Fly    57 DADPVQMRRILDELEEEVYEINAEQQFLLLRLN-------------DSLQEFSVKLKE------- 101
            .|.....:.|..|:|.:..::..:::|..||.:             |...:..::|.|
  Fly  2068 QAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPKIELRLDEALSQAYY 2132

  Fly   102 NNI--MFLPDIAHEYVSAQV-VPLIVDPN-YKIMPQSVMARDTE--------------------E 142
            :||  |.|..: ..|:...: :||.:.|: ::::.|..:|...|                    |
  Fly  2133 HNIANMSLSSV-QTYIPIDIPLPLSMTPDEHRLLEQVKLAGFPERVHGVYVPRRQRYGWWQLDDE 2196

  Fly   143 MLIRKHFLLSQDDDSGMPPLKLSELDENI--------PL---------------MLAPPVRG--- 181
            ..:|:  ||...:.||   |:..||.||:        ||               .|.|..:|
  Fly  2197 QKLRQ--LLKTLNPSG---LRERELQENLQRFLGLEQPLGVNYKLKSDIDFPEEFLMPDKKGDWN 2256

  Fly   182 --LGQQI-AAVKPEPEWLQGDEATVSVP----PPPPQSKSKLMKGSLDS------------TPAK 227
              :.::: .|:..:.|.|:...|:.|:.    ..|.:.:|:|   :|||            .|..
  Fly  2257 PKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVESEL---TLDSQEDVTEEDFVSIIPMI 2318

  Fly   228 RENI--------SRSSPPPLAPITQTVVAELSQVPPSPQAESPPVNFHVVAQSRKNLQQA--LRR 282
            ||.|        .|...|||.  :||..|.|:.:..         |.|...|::.:...|  |.:
  Fly  2319 RERIIDLEANIERRYLKPPLG--SQTGDAHLAVIAQ---------NQHTTTQTQNSASAAAYLLQ 2372

  Fly   283 ARKTKQQPRLFDDEEDLEITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMA 347
            .::.:||.:|...::              :...|.|...||.|::......|.......|..|
  Fly  2373 MQQQQQQQQLAQQQQ--------------QQQQGSGAGNSLNPSSFNERTMALAAAAAASGPG-- 2421

  Fly   348 KNNTAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQ 412
              |.....|:...:..||..||..:|...::..:.:..::..::.::......||||....|.|.
  Fly  2422 --NATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTT 2484

  Fly   413 PE----EYGQETFL----GLFELYSPE---------------VLKKLSQRHSKRKRRTVQNASGV 454
            .:    .|..|:.:    .:.:.|:.:               ..||..|:.:|::::...|  |.
  Fly  2485 AQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPN--GK 2547

  Fly   455 DFHYGQQLN----------AVDALVMGVRGQKKTKEKSEFLL------SPTEKRLQANSKRTYTR 503
            :......:|          .::...:...||...|.|:..:|      ||:.....::|...:.:
  Fly  2548 ESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFGK 2612

  Fly   504 KSKSPDEISEKSSAGGGSGASGTASSSACQHKDGGASK-----CRKCRE---------------- 547
            ::|.......:.||...:.:..:.|...||....|.::     |..|.:
  Fly  2613 RTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPD 2677

  Fly   548 ----CRECKRRVETE----------------AMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPP 592
                |.||..:...|                .:||.||...||.||:               .||
  Fly  2678 GDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCY---------------IPP 2727

  Fly   593 CLR 595
            .|:
  Fly  2728 LLK 2730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lint-1	NP_001285113.1	PHD	548..593	CDD:214584	13/60 (22%)
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	11/38 (29%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	6/44 (14%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	4/18 (22%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	4/17 (24%)
		PHD	2695..2744	CDD:279022	11/51 (22%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900