DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lint-1 and let-418

DIOPT Version :9

Sequence 1:	NP_001285113.1	Gene:	Lint-1 / 32055	FlyBaseID:	FBgn0030274	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_504523.1	Gene:	let-418 / 178970	WormBaseID:	WBGene00002637	Length:	1829	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	68/361 - (18%)
Similarity:	110/361 - (30%)	Gaps:	126/361 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 TKQQPRLFDDEEDLEITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMAKNN 350
            |::.|.|.|.||.:|..|:..|..:....:     ...|..:.|.....|::..:...:|..|.:
Worm     3 TEEDPSLVDAEESMEEGSVTQDATEETEEE-----EEQEQGDEAGPSERKRSSRKKGGKGGKKGS 62

  Fly   351 TAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPEE 415
            ...:....:...|.|.:| .|:...::.|.:|   .|.                          :
Worm    63 KKSAAAASKVEIPDPYNS-TSEEVCAAIGLTD---VEF--------------------------D 97

  Fly   416 YGQETFLGLFEL------YSPEVLK------------------KLSQRHSKRKRRTVQNASGVDF 456
            |.:|.|.|:..|      ..|::|:                  |..|.|...:.:.||..:
Worm    98 YDEEEFQGISNLKTFSSIIKPQILEANPGTNVSKMYPMFQVKYKEYQDHMAAQGKPVQKQA---- 158

  Fly   457 HYGQQLNAVDALVMGVRGQKKTKEKSEFLLSPTEKRLQANSKRTYTRKSKSPDEISE-------- 513
             .|.:..||...|:..|.            :||:.|    |.|...|.|.:||...|
Worm   159 -RGSKTPAVSTPVIPPRS------------APTKTR----SARRKRRDSDAPDSDQEFEAFIKQQ 206

  Fly   514 ----------------KSSAGGGSGASGTASSSACQHKDGGASKCRKCRE------CRECKRRVE 556
                            |.:|.......|...::....|    :|..|..|      |.|||:  :
Worm   207 EQLEDDLVKDKEDARIKRAAEREEKKKGALEAARAAKK----AKLEKGEEAENNDYCEECKQ--D 265

  Fly   557 TEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPP 592
            .|.:.|..|...||..|.:          :|...||
Worm   266 GELLLCDTCPRAYHTVCID----------ENMEEPP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lint-1	NP_001285113.1	PHD	548..593	CDD:214584	13/45 (29%)
let-418	NP_504523.1	CHDNT	95..147	CDD:285335	10/77 (13%)
		TNG2	<151..300	CDD:227367	37/178 (21%)
		PHD1_CHD_II	258..300	CDD:277006	13/46 (28%)
		RanBP2-type Zn finger	295..323	CDD:275375
		PHD_SF	320..362	CDD:304600
		CHROMO	367..449	CDD:237991
		CHROMO	489..543	CDD:214605
		SNF2_N	605..901	CDD:278600
		DEXDc	622..780	CDD:238005
		Helicase_C	925..1040	CDD:278689
		DUF1087	1188..1238	CDD:283996
		DUF1086	1276..1406	CDD:283992
		CHDCT2	1524..1698	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900