DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lint-1 and Aire

DIOPT Version :10

Sequence 1:NP_572692.1 Gene:Lint-1 / 32055 FlyBaseID:FBgn0030274 Length:602 Species:Drosophila melanogaster
Sequence 2:NP_033776.1 Gene:Aire / 11634 MGIID:1338803 Length:552 Species:Mus musculus


Alignment Length:585 Identity:126/585 - (21%)
Similarity:190/585 - (32%) Gaps:171/585 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 MRRILDELEEEVYEINAEQQFLLLRL--------NDSLQEFSVKLKENNIMFLPDIAHEYVSAQV 119
            :||:| .|......:..:..|.||..        .|..|| :::|||..  ..|...|..:|.  
Mouse     8 LRRLL-RLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQE-TLRLKEKE--GCPQAFHALLSW-- 66

  Fly   120 VPLIVDPNYKIMP-QSVMARDTE-EMLIRKHFLLSQDDDSGMPPLKLSELDENIPLMLAPPVRGL 182
              |:...:..|:. ..::.:|.. |...|.|.:|     .|.|    .::|             |
Mouse    67 --LLTRDSGAILDFWRILFKDYNLERYSRLHSIL-----DGFP----KDVD-------------L 107

  Fly   183 GQQIAAVKPEPEWLQGDEATVSVPPPPPQSKSKLMKGSLDSTPAKRENISRSSP-------PPLA 240
            .|.....||    |.|.:|.| :||.|| :|.|.::....:.||...:.|.|||       ||..
Mouse   108 NQSRKGRKP----LAGPKAAV-LPPRPP-TKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKK 166

  Fly   241 PI-------------TQTVVAELSQVPPSPQAESPPVNFHVVAQSRKNLQQALRRARKTK----- 287
            |.             .||:.|.:.:.......:.|.....|....   :||.....|..|     
Mouse   167 PDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGIL---IQQVFESGRSKKCIQVG 228

  Fly   288 ---QQPRLFDDEEDLEITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMAKN 349
               ..|..|:|...       |.:||.|:..      ||:|...|  :.|:.|||....|.:.  
Mouse   229 GEFYTPNKFEDPSG-------NLKNKARSGS------SLKPVVRA--KGAQVTIPGRDEQKVG-- 276

  Fly   350 NTAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPE 414
                     ::....|..|..|:|.|:.  .::|..|......:.......     ||       
Mouse   277 ---------QQCGVPPLPSLPSEPQVNQ--KNEDECAVCHDGGELICCDGC-----PR------- 318

  Fly   415 EYGQETFLGLFEL--YSP---EVLKKLSQRHSKRKRRTVQNASGVDFHYGQQLNAVDALVMGVR- 473
                     .|.|  .||   |:...|.:.....:.|..||.|..:.....:|.|...:::|:| 
Mouse   319 ---------AFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRS 374

  Fly   474 GQKKTKEKSEFLLSPTEKRLQANSKRTYTRKS----------KSPDEISEKSSAGGGSGASGTAS 528
            ..:||:..|        :.|:|:|....|..:          ..|..:....|| |..|..|.|.
Mouse   375 ASEKTRGPS--------RELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSA-GNEGRPGPAP 430

  Fly   529 SSACQHKDGGASKCRKCRECRECKRRVETEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPPC 593
            |:.|.....|                  ||.:.|..|:..:|..||..|...:  ...|.||..|
Mouse   431 SARCSVCGDG------------------TEVLRCAHCAAAFHWRCHFPTAAAR--PGTNLRCKSC 475

  Fly   594  593
            Mouse   476  475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lint-1NP_572692.1 PHD 548..593 CDD:214584 11/44 (25%)
AireNP_033776.1 LXXLL motif 1 8..12 2/3 (67%)
HSR 17..104 CDD:460835 21/102 (21%)
LXXLL motif 2 64..68 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..177 22/73 (30%)
Nuclear localization signal. /evidence=ECO:0000255 114..134 11/25 (44%)
SAND 198..264 CDD:128554 17/83 (20%)
PHD1_AIRE 300..342 CDD:277014 9/62 (15%)
LXXLL motif 3 414..418 0/3 (0%)
PHD2_AIRE 433..475 CDD:277015 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..514 2/4 (50%)
LXXLL motif 4 520..524
Blue background indicates that the domain is not in the aligned region.

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