DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lint-1 and Aire

DIOPT Version :9

Sequence 1:NP_001285113.1 Gene:Lint-1 / 32055 FlyBaseID:FBgn0030274 Length:602 Species:Drosophila melanogaster
Sequence 2:NP_033776.1 Gene:Aire / 11634 MGIID:1338803 Length:552 Species:Mus musculus


Alignment Length:585 Identity:126/585 - (21%)
Similarity:190/585 - (32%) Gaps:171/585 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 MRRILDELEEEVYEINAEQQFLLLRL--------NDSLQEFSVKLKENNIMFLPDIAHEYVSAQV 119
            :||:| .|......:..:..|.||..        .|..|| :::|||..  ..|...|..:|.  
Mouse     8 LRRLL-RLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQE-TLRLKEKE--GCPQAFHALLSW-- 66

  Fly   120 VPLIVDPNYKIMP-QSVMARDTE-EMLIRKHFLLSQDDDSGMPPLKLSELDENIPLMLAPPVRGL 182
              |:...:..|:. ..::.:|.. |...|.|.:|     .|.|    .::|             |
Mouse    67 --LLTRDSGAILDFWRILFKDYNLERYSRLHSIL-----DGFP----KDVD-------------L 107

  Fly   183 GQQIAAVKPEPEWLQGDEATVSVPPPPPQSKSKLMKGSLDSTPAKRENISRSSP-------PPLA 240
            .|.....||    |.|.:|.| :||.|| :|.|.::....:.||...:.|.|||       ||..
Mouse   108 NQSRKGRKP----LAGPKAAV-LPPRPP-TKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKK 166

  Fly   241 PI-------------TQTVVAELSQVPPSPQAESPPVNFHVVAQSRKNLQQALRRARKTK----- 287
            |.             .||:.|.:.:.......:.|.....|....   :||.....|..|     
Mouse   167 PDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGIL---IQQVFESGRSKKCIQVG 228

  Fly   288 ---QQPRLFDDEEDLEITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMAKN 349
               ..|..|:|...       |.:||.|:..      ||:|...|  :.|:.|||....|.:.  
Mouse   229 GEFYTPNKFEDPSG-------NLKNKARSGS------SLKPVVRA--KGAQVTIPGRDEQKVG-- 276

  Fly   350 NTAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPE 414
                     ::....|..|..|:|.|:.  .::|..|......:.......     ||       
Mouse   277 ---------QQCGVPPLPSLPSEPQVNQ--KNEDECAVCHDGGELICCDGC-----PR------- 318

  Fly   415 EYGQETFLGLFEL--YSP---EVLKKLSQRHSKRKRRTVQNASGVDFHYGQQLNAVDALVMGVR- 473
                     .|.|  .||   |:...|.:.....:.|..||.|..:.....:|.|...:::|:| 
Mouse   319 ---------AFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRS 374

  Fly   474 GQKKTKEKSEFLLSPTEKRLQANSKRTYTRKS----------KSPDEISEKSSAGGGSGASGTAS 528
            ..:||:..|        :.|:|:|....|..:          ..|..:....|| |..|..|.|.
Mouse   375 ASEKTRGPS--------RELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSA-GNEGRPGPAP 430

  Fly   529 SSACQHKDGGASKCRKCRECRECKRRVETEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPPC 593
            |:.|.....|                  ||.:.|..|:..:|..||..|...:  ...|.||..|
Mouse   431 SARCSVCGDG------------------TEVLRCAHCAAAFHWRCHFPTAAAR--PGTNLRCKSC 475

  Fly   594  593
            Mouse   476  475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lint-1NP_001285113.1 PHD 548..593 CDD:214584 11/44 (25%)
AireNP_033776.1 LXXLL motif 1 8..12 2/3 (67%)
Sp100 17..103 CDD:281203 21/101 (21%)
LXXLL motif 2 64..68 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..177 22/73 (30%)
Nuclear localization signal. /evidence=ECO:0000255 114..134 11/25 (44%)
SAND 198..264 CDD:128554 17/83 (20%)
PHD1_AIRE 300..342 CDD:277014 9/62 (15%)
LXXLL motif 3 414..418 0/3 (0%)
PHD2_AIRE 433..475 CDD:277015 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..514 2/4 (50%)
LXXLL motif 4 520..524
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0383
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.