DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lint-1 and PHF21B

DIOPT Version :9

Sequence 1:	NP_001285113.1	Gene:	Lint-1 / 32055	FlyBaseID:	FBgn0030274	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_612424.1	Gene:	PHF21B / 112885	HGNCID:	25161	Length:	531	Species:	Homo sapiens

Alignment Length:	441	Identity:	96/441 - (21%)
Similarity:	146/441 - (33%)	Gaps:	148/441 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 APPVRG--------LGQQIAAVKPE--PEWLQGDEATVSV----PP--PPPQSKSKL--MKGSLD 222
            |.||.|        |..|.|||.|:  |:.|..|...|:.    ||  ||...|:.:  :|....
Human    47 AVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVAPGRDRPPKQPPTFQKATVVSVKNPSP 111

  Fly   223 STPAKRENISR-----SSPPPLA-------PITQTVVAE--LSQVPPSPQAESPPVNFHVVAQSR 273
            :.|.....:|.     |.|..||       |::...||.  :|..|.:..|.:|.....||:.|.
Human   112 ALPTANNTVSHVPAPGSQPQALAEPAALASPLSSAGVAYAIISTSPSNAAAMAPSTAVSVVSDSI 176

  Fly   274 KNLQQALRRARKTKQQPRLFDDEE------DLEITSLQNDRNKNRTSDGKGTP--PSLEPTNAAA 330
            |  .|.|..:...|..|||.....      .|..:||..            ||  |||.|:....
Human   177 K--VQPLLISADNKPPPRLLSSPHPATHHCPLHPSSLPL------------TPPSPSLSPSPLHG 227

  Fly   331 NQAAKKTIPQMSSQGMAKNNTAKSKNTCRKSSPTPTSSGQSQPAVSSSGSSDDSSAELQQEQQRR 395
            ........||:.:|                    |.|:.:|:|..               |:..:
Human   228 IFQVIIIQPQVQTQ--------------------PESTAESRPPT---------------EEPSQ 257

  Fly   396 VASAAQWRDEPR-ESRTQPEEYGQETFLGLFELYSPEVLKKLSQRHSKRKRRTVQNASGVDFHYG 459
            .|.|.:.:.|.| .::..||:......||   |.:.|.|:::..:..:||||:..|.:
Human   258 GAQATKKKKEDRPPTQENPEKIAFMVALG---LVTTEHLEEIQSKRQERKRRSTANPA------- 312

  Fly   460 QQLNAVDALVMGVRGQKKTKEKSEFLLSPTEKRLQANSKRTYTRKSKSPDEISEKSSAGGGSGAS 524
                     ..|:...::.:..|.:|.:|.....:||....:      .:||:
Human   313 ---------YSGLLETERKRLASNYLNNPLFLTARANEDPCW------KNEIT------------ 350

  Fly   525 GTASSSACQHKDGGASKCRKCRECRECKRRVETEAMYCHLCSGLYHMDCHE 575
                     |.:          .|..|||....:.  |..|.|.||:.|.|
Human   351 ---------HDE----------HCAACKRGANLQP--CGTCPGAYHLSCLE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lint-1	NP_001285113.1	PHD	548..593	CDD:214584	11/28 (39%)
PHF21B	NP_612424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..99		6/19 (32%)
		Nuc_recep-AF1	108..193	CDD:288658	21/86 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..222		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..277		10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..314		5/34 (15%)
		PHD_PHF21B	354..396	CDD:276999	11/29 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900