DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lint-1 and CHD4

DIOPT Version :9

Sequence 1:	NP_001285113.1	Gene:	Lint-1 / 32055	FlyBaseID:	FBgn0030274	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001264.2	Gene:	CHD4 / 1108	HGNCID:	1919	Length:	1912	Species:	Homo sapiens

Alignment Length:	513	Identity:	91/513 - (17%)
Similarity:	152/513 - (29%)	Gaps:	196/513 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 GLGQQIAAVKPEPEWLQGDEATV------SVPPPPPQSKSKLMKGSLDSTPAKRENISRSSPPPL 239
            |||      .|.|.....:|..:      |:|||.|:::..           ..|::|.:..|.|
Human     4 GLG------SPSPCSAGSEEEDMDALLNNSLPPPHPENEED-----------PEEDLSETETPKL 51

  Fly   240 APITQTVVAELSQVPPSPQAESPPVNFHVVAQSRKNLQQALRRARK----TKQQPRLFDDEEDLE 300
                     :..:.|..|:....|       :|::..::.:...|:    :.:.|...::||::
Human    52 ---------KKKKKPKKPRDPKIP-------KSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEV- 99

  Fly   301 ITSLQNDRNKNRTSDGKGTPPSLEPTNAAANQAAKKTIPQMSSQGMAKNNTAKSKNTCRKSSPTP 365
              :|::|      |:|....|         .:..||.:      |..|...:|||   ||...
Human   100 --ALRSD------SEGSDYTP---------GKKKKKKL------GPKKEKKSKSK---RKEEE-- 136

  Fly   366 TSSGQSQPAVSSSGSSDDSSAELQQEQQRRVASAAQWRDEPRESRTQPEEYGQETF--------- 421
                      ......|||.                   ||:.|....|::|.|..
Human   137 ----------EEEDDDDDSK-------------------EPKSSAQLLEDWGMEDIDHVFSEEDY 172

  Fly   422 --LGLFELYSPEVLKKLSQRHSK---RKRRTVQNASGVDF--------HYGQQLNAVDALVMGV- 472
              |..::.:|..|...::.::.|   .|...|..|...:|        ..|..:.|..|..:.|
Human   173 RTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVV 237

  Fly   473 -------------------RGQKKTKEKSEFLLSPTEKRLQANSKRTYTRKSKSPDEISEKSSAG 518
                               ..:.||||..    .|..:|....|.|....|...|.:::......
Human   238 ESMVTATEVAPPPPPVEVPIRKAKTKEGK----GPNARRKPKGSPRVPDAKKPKPKKVAPLKIKL 298

  Fly   519 GGSGASGTASSS-----------------ACQHKDGGASKCRKCRE------------------- 547
            ||.|:....|||                 :....||..|:..:.|:
Human   299 GGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVD 363

  Fly   548 ---------CRECKRRVETEAMYCHLCSGLYHMDCHEFTKNRQLMQLQNSRCPPCLRE 596
                     |..|::  ..|.:.|..|...|||.|  ...:.:........||.|.:|
Human   364 GYETDHQDYCEVCQQ--GGEIILCDTCPRAYHMVC--LDPDMEKAPEGKWSCPHCEKE 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lint-1	NP_001285113.1	PHD	548..593	CDD:214584	11/44 (25%)
CHD4	NP_001264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157		43/243 (18%)
		CHDNT	164..216	CDD:285335	8/51 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..360		20/120 (17%)
		PHD1_CHD_II	372..414	CDD:277006	11/45 (24%)
		PHD2_CHD_II	451..493	CDD:277007
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..538
		CHROMO	<540..577	CDD:237991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..603
		CHROMO	622..676	CDD:214605
		SNF2_N	729..1025	CDD:278600
		DEXDc	746..904	CDD:238005
		DEAH box	873..876
		Helicase_C	1068..1164	CDD:278689
		DUF1087	1302..1352	CDD:283996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1401
		DUF1086	1385..1521	CDD:283992
		Neuromodulin	<1517..1649	CDD:284117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1525..1562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1589
		Required for interaction with PCNT. /evidence=ECO:0000269\|PubMed:17626165	1577..1912
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1594..1644
		CHDCT2	1726..1896	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900