DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK2AP1 and MPHOSPH9

DIOPT Version :9

Sequence 1:	NP_001259439.1	Gene:	CDK2AP1 / 32050	FlyBaseID:	FBgn0030269	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_073619.3	Gene:	MPHOSPH9 / 10198	HGNCID:	7215	Length:	1183	Species:	Homo sapiens

Alignment Length:	284	Identity:	58/284 - (20%)
Similarity:	91/284 - (32%)	Gaps:	110/284 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SQVQNFYNYQQQREQREQQPQIQISAIHHSRGSVGGGGGSNSSNAATDYSTSSGGKRERDRSSAS 88
            :|.:.|:| |.|..|.|.:..:::.....|..|..|    ||||           |:....|...
Human   106 AQQEQFHN-QIQHIQEEIKNLVKLQTSSASLASCEG----NSSN-----------KQVSSESQMG 154

  Fly    89 DYSSSSSKQSSAAAANAAAAAAAVAALQYSPQFLQAQLALLQQQSNTTATPAAVAAAALSLANMC 153
            .:|.||.:..|              .:.| |:..:.::    ||..:|:.|.            |
Human   155 FFSLSSERNES--------------VIHY-PESTEPEI----QQEMSTSQPD------------C 188

  Fly   154 SSNGGQRNSGAGVSSTSSGSNGQSMGLNLSSSQ--------LKYPP--------PSTSPVVVTTQ 202
            :.:....:||.|....|.        |||..|:        :..|.        |:.|.|.....
Human   189 NVDSCSVSSGYGTFCISE--------LNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKN 245

  Fly   203 TSANITTPLTSTASLP---SVGPG----------------------NGLTKYAQLL-------AV 235
            .:..|.||.....||.   |:.||                      |.:|.:||.|       |.
Human   246 ENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAH 310

  Fly   236 IEEMGRDIRPTYTGSRSSTERLKR 259
            :|:.|       :.|:...|:.|:
Human   311 VEDGG-------SRSKQGNEQSKK 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK2AP1	NP_001259439.1	CDK2AP	1..280	CDD:286844	58/284 (20%)
MPHOSPH9	NP_073619.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..334		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..495
		Rootletin	621..795	CDD:291694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4713
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900