Protein Alignment Klp10A and KIF2B

DIOPT Version :10

• Sequence 1: NP_572687.1
• Gene: Klp10A / 32049
• FlyBaseID: FBgn0030268
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_115948.4
• Gene: KIF2B / 84643
• HGNCID: 29443
• Length: 673
• Species: Homo sapiens
• Alignment Length: 803
• Identity: 312/803 - (38%)
• Similarity: 432/803 - (53%)
• Gaps: 187/803 - (23%)

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |..|..|.|:|:|.|:|:|||..||:....:||||.|:...|||:::|:.||.|||.|  |:.|
Human    26 IQEGIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPAL--DSAE- 87

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNS 133
            |..|.|      |::                                  |..:..|:::...
Human    88 HPMPPP------PLS----------------------------------PLALAPSSAIRDQ--- 109

  Fly   134 NTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVATAAT 198
                      .|:|......|:.:|.|:|..   :...||:.            |...
Human   110 ----------RTATKWVAMIPQKNQTASGDS---LDVRVPSK------------PCLM------- 142

  Fly   199 TQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQSTL 263
                   ..::|..|.|:::|:|.|||||..|.|::..:.  ::.:..|||:|...||.||:..|
Human   143 -------KQKKSPCLWEIQKLQEQREKRRRLQQEIRARRA--LDVNTRNPNYEIMHMIEEYRRHL 198

  Fly   264 EFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHK 328
            :...:...:...:|:|.|||||||::::|...|::|:|:||..::::|||.:.|||||::|:|..
Human   199 DSSKISVLEPPQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQT 263

  Fly   329 FRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGI 393
            |.||:||:|...|.:||::||:|||::||..||||||||||||||||:||||:|:|..|||..||
Human   264 FCFDHAFDDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGI 328

  Fly   394 YAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKV 458
            ||:.|:|||:.|....|..::|.|..:|||||.|||:|||:.|:||:|||||.||:|||||.||.
Human   329 YALVAQDVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEKE 393

  Fly   459 VDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKI-HGKFSFIDLAGNERGV 522
            |..|||||.|::.||:.|||.||..|::||||||||||:|:   |.:| |||||.:||||||||.
Human   394 VCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILK---SGRIMHGKFSLVDLAGNERGA 455

  Fly   523 DTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMI 587
            ||:.|.|:.::||||||||||||||||.|||:...|.|||.||||.||||||||:.|.|||||.|
Human   456 DTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFIGQNSSTCMIATI 520

  Fly   588 SPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHSHQLHPNS 652
            |||::|||:||||||||:|||:|.|.                           |.|:....:|..
Human   521 SPGMTSCENTLNTLRYANRVKKLNVD---------------------------VRPYHRGHYPIG 558

  Fly   653 H-APASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELI----VQHQ 712
            | ||       |...||                  .||.::::        ..||.|    ||.:
Human   559 HEAP-------RMLKSH------------------IGNSEMSL--------QRDEFIKIPYVQSE 590

  Fly   713 AIDDLQQTEEMVVEYHRTVNATLETFLAE---------SKALYNL---TNYVDYDQDSYCKRGES 765
            ...::::.|            ||.|.|.:         |:.|.|:   ...|.:|.|....|..|
Human   591 EQKEIEEVE------------TLPTLLGKDTTISGKGSSQWLENIQERAGGVHHDIDFCIARSLS 643

  Fly   766 MFSQLLDIAIQCRDMMAEYRAKL 788
            :..|.:       |.:.|.:.||
Human   644 ILEQKI-------DALTEIQKKL 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_572687.1	KISc_KIF2_like	278..608	CDD:276818	207/330 (63%)
KIF2B	NP_115948.4	KISc_KIF2_like	213..541	CDD:276818	207/330 (63%)