DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and Kif2a

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_445828.1	Gene:	Kif2a / 84391	RGDID:	70974	Length:	705	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	380/799 - (47%)
Similarity:	495/799 - (61%)	Gaps:	112/799 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |.:|..|:|||:|||:|.|:|..:|:..:.:||||.|.|:|||||::|::|.:|||:|:.|
  Rat     9 IQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPD---- 69

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSS--NSVNTNS 131
                                                    ..|:.|..||.|..||  |.:..|.
  Rat    70 ----------------------------------------EDIEPSPEIPPPSSSSKVNKIVKNR 94

  Fly   132 NSNTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVA-T 195
            .:..:.........:...|..|.|.||                  ||..|::|....:...:: .
  Rat    95 RTVASIKNDPPPRDNRVVGSARARPSQ------------------LPEQSSSAQQNGSVSDISPV 141

  Fly   196 AATTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQ 260
            .|..:..|..|.|:|:.:||||:|:|.|||||.:|.|::|::.  .:.|..|||:|...|||:::
  Rat   142 QAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRA--QDVDATNPNYEIMCMIRDFR 204

  Fly   261 STLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLE 325
            .:|::.||.....:|:|:|.|||||||:::||...|::|||::|.||:::||||:.|||||::||
  Rat   205 GSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLE 269

  Fly   326 NHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCK 390
            |..|||||||:|:..|.|||::||:|||:||||.|||||||||||||||||||||:|:||.|||.
  Rat   270 NQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCS 334

  Fly   391 NGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLT 455
            .||||:||:|||:.|..|.|:.:.|.|.|:|||||||||||||:.|.|||||||||||||||||.
  Rat   335 KGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQ 399

  Fly   456 EKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNER 520
            |:.|..||:|||||..||:.|||||||||::||||||||||:||.:|  |:|||||.||||||||
  Rat   400 EREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFSLIDLAGNER 462

  Fly   521 GVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIA 585
            |.||||||||||:||||||||||||||||||||:...|.|||.||||||||||||||.|:|||||
  Rat   463 GADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIA 527

  Fly   586 MISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHSHQLHP 650
            .||||::|||:||||||||:|||||.    |:....||..||            |.||.| |:..
  Rat   528 TISPGMASCENTLNTLRYANRVKELT----VDPTAAGDVRPI------------MHHPPS-QIDD 575

  Fly   651 NSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQAID 715
            ........|:.||.                          ||.:|...:|.|:|.:|...|:|:.
  Rat   576 LETQWGVGSSPQRD--------------------------DLKLLCEQNEEEVSPQLFTFHEAVS 614

  Fly   716 DLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLLDIAIQCRDM 780
            .:.:.||.|||.||.|......::.:.|||..:|..||||.|||..:.|::..|.:||..:.||.
  Rat   615 QMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDK 679

  Fly   781 MAEYRAKLAKEEMLSCSFN 799
            :..:||.|.:||..|...|
  Rat   680 VKSFRAALQEEEQASKQIN 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	241/329 (73%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	238/324 (73%)
Kif2a	NP_445828.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..185		39/183 (21%)
Kif2a	NP_445828.1	KISc_KIF2_like	222..550	CDD:276818	241/329 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I378
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3320
Inparanoid	1	1.050	668	1.000	Inparanoid score	I714
OMA	1	1.010	-	-		QHG45607
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm45791
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980