DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and KINESIN-13A

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_188285.1	Gene:	KINESIN-13A / 820915	AraportID:	AT3G16630	Length:	794	Species:	Arabidopsis thaliana

Alignment Length:	845	Identity:	260/845 - (30%)
Similarity:	379/845 - (44%)	Gaps:	215/845 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNSNTTAGGGGGTTTSTTTGLQ 152
            ||..| |..:.:|...:..:       |.:.:|:.|:.:...:..:....|.|
plant    22 PTNDA-GDAVMARWLQSAGL-------QHLASPVASTGNDQRHLPNLLMQGYG------------ 66

  Fly   153 RPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVATAATTQG------AG--GASTRR 209
                  |.|.:::.|:...:.|......|.:.|..|.|...|...:::|      .|  ||....
plant    67 ------AQTAEEKQRLFQLMRNLNFNGESTSESYTPTAHTSAAMPSSEGFFSPEFRGDFGAGLLD 125

  Fly   210 SHALKEVERLKE----------------------------NREKRRARQAEMKEEKVALMNQDPG 246
            .||:.:.|.|.|                            ||::|:..:||
plant   126 LHAMDDTELLSEHVITEPFEPSPFMPSVNKEFEEDYNLAANRQQRQQTEAE-------------- 176

  Fly   247 NPNWETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIV 311
                           .|..:|..|.:.....:|.|.|||||:::||..:||.||::| ..:.|.|
plant   177 ---------------PLGLLPKSDKENNSVAKIKVVVRKRPLNKKETAKKEEDVVTV-SDNSLTV 225

  Fly   312 HEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTH 376
            ||||.|||||.::|.|:|.||...::...|..||:.|.:|::..||:...||||||||||||||.
plant   226 HEPRVKVDLTAYVEKHEFCFDAVLDEDVSNDEVYRATIEPIIPIIFQRTKATCFAYGQTGSGKTF 290

  Fly   377 TMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRV 441
            ||            ..:...|.:|:...|..|.|......:..|:||||.||:|||||:::||.:
plant   291 TM------------KPLPIRAVEDLMRLLRQPVYSNQRFKLWLSYFEIYGGKLFDLLSERKKLCM 343

  Fly   442 LEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGST-- 504
            .|||:|||.:|||.|..|..|:.|...|:.|||.|::|.|.||..||||||:.|:|::.....
plant   344 REDGRQQVCIVGLQEYEVSDVQIVKDFIEKGNAERSTGSTGANEESSRSHAILQLVVKKHVEVKD 408

  Fly   505 -------------KIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQS 556
                         |:.||.|||||||:|||.||:..|||||:|||||||||||||||||||....
plant   409 TRRRNNDSNELPGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDNDQ 473

  Fly   557 AHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKEL-----VVKD-I 615
            .|:|||.||||:||||||:| .|:|.||:.|||...||||||||||||||||.|     ..|| .
plant   474 LHIPFRGSKLTEVLRDSFVG-NSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSKSGNSKKDQT 537

  Fly   616 VEVCPGGDTEPIEITDDEEE-----EELNMVHPHSHQLHPNSHAPAS-----QSNNQR------- 663
            ....|..:.:|:...:|.|:     :|:|:.......:..:|::..|     |..|.|
plant   538 ANSMPPVNKDPLLGPNDVEDVFEPPQEVNVPETRRRVVEKDSNSSTSGIDFRQPTNYREESGIPS 602

  Fly   664 --------APASHHSGAVIHNNN---------------------------------NNNNKNGNA 687
                    .|.|..:|:....||                                 ..|....:.
plant   603 FSMDKGRSEPNSSFAGSTSQRNNISSYPQETSDREEKVKKVSPPRGKGLREEKPDRPQNWSKRDV 667

  Fly   688 GNMDLAMLSSLSEHEMSDELIVQHQA--------------IDDLQQTEEMVVEYHR-TVNATLET 737
            .:.|:..|::..:: .|:....|::.              :|.|.:.||.::..|| .:..|:|.
plant   668 SSSDIPTLTNFRQN-ASETASRQYETASRQYETDPSLDENLDALLEEEEALIAAHRKEIEDTMEI 731

  Fly   738 FLAESKALYN-------LTNYVDYDQDSYCKRGESMFSQLLDIAIQCRDMMAEYRAKLAKEEMLS 795
            ...|.|.|..       :.|||........::...:      :::|.|  :|.::.:|.::|:||
plant   732 VREEMKLLAEVDQPGSMIENYVTQLSFVLSRKAAGL------VSLQAR--LARFQHRLKEQEILS 788

Fly 796 795
plant 789 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	177/344 (51%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	175/339 (52%)
KINESIN-13A	NP_188285.1	SAM_superfamily	29..84	CDD:417767	10/79 (13%)
KINESIN-13A	NP_188285.1	KISc_KIF2_like	193..524	CDD:276818	177/344 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	319	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I681
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D418348at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1030
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730