DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and kif2c

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001006856.1	Gene:	kif2c / 448620	XenbaseID:	XB-GENE-961445	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	819	Identity:	332/819 - (40%)
Similarity:	469/819 - (57%)	Gaps:	131/819 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQ----- 63
            :..|..|||.|::|.:|.|.:..:|.....:.|||.|....||||:....::::||||:.
Frog     9 LVTGLVVKIMRSNGVIHNASITSVNMDRSSVNVEWKEGDANKGKEISFADVISVNPELLDAVLAP 73

  Fly    64 DTVEQHAAPE------------------PKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNML-- 108
            ..|:::..|:                  ||:..|....|.....||.:....| |||.....|
Frog    74 PNVKENMPPQRNVPSQNQKRKTISKIPAPKEVTTQNSLLPEYGAQSVLRERST-RMTAIHEALPS 137

  Fly   109 -NKIQ-ESQSIPNPIVSSNSVNTNSNSNTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASA 171
             |::: ||..:|   |..||:....:.:|.|                   |.|...:.|.|| |.
Frog   138 ENEMEVESTVLP---VQQNSIQVGRSRSTKA-------------------SVAGELRSQPRI-SE 179

  Fly   172 VPNNTLPNPSAAASAGPAAQGVATAATTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEE 236
            :...:||         |.....|            .|:|:.:||:|::|..||::||:.:|::.:
Frog   180 IVEESLP---------PVRNNQA------------RRKSNIVKEMEKMKNKREEQRAQNSELRIK 223

  Fly   237 KVALMNQDPGNPNWETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVI 301
            :.  .:.|...||||..:||:::::|::...:......::|:|.|||||||::::|:::||||:|
Frog   224 RA--QDYDTSIPNWEFGKMIKDFRATMDCHRISMADPAEEHRICVCVRKRPLNKQELSKKEIDII 286

  Fly   302 SVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFA 366
            |||.|::::||||:.||||||:|||..|||||:|::|..|.:||::||:|||::|||||.|||||
Frog   287 SVPSKNIVLVHEPKLKVDLTKYLENQPFRFDYSFDETATNEVVYRFTARPLVQSIFEGGKATCFA 351

  Fly   367 YGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFD 431
            ||||||||||||||:|:||.|:...|:||.|::|||:.|:.|||:.::|.|..:|||||:|||||
Frog   352 YGQTGSGKTHTMGGDFSGKSQNVSKGVYAFASRDVFLLLDQPRYKHLDLDVFVTFFEIYNGKVFD 416

  Fly   432 LLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQI 496
            ||:.|.|||||||.||:||||||.|:.|...::|.|:|:.|:|.||||||.|||:||||||..||
Frog   417 LLNKKAKLRVLEDAKQEVQVVGLLERQVTSADDVFKMIEVGSACRTSGQTFANSSSSRSHACLQI 481

  Fly   497 VLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPF 561
            :|| :|| |:|||||.:||||||||.||:||||.|||||||||:|||||||||||||:..:|.||
Frog   482 ILR-RGS-KLHGKFSLVDLAGNERGADTASADRITRMEGAEINRSLLALKECIRALGQNKSHTPF 544

  Fly   562 RVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEP 626
            |.|||||:||||||||.|:||||||:|||.:|||:||||||||||||||            ..:.
Frog   545 RESKLTQILRDSFIGENSRTCMIAMLSPGFNSCEYTLNTLRYADRVKEL------------SPQN 597

  Fly   627 IEITDDEEEEELNMVHPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMD 691
            .|..||..:.|                                       ..:::..:.:.|.:.
Frog   598 AETNDDNLQME---------------------------------------TEDSDGSHASIGGLQ 623

  Fly   692 LAMLSSLSEHEMSDELIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQ 756
            |.....|.:.|:|..:.....|::.:.:.||..||..|    .|.....|...|...|...|||.
Frog   624 LQDDFLLKDEELSTHINSFQDALNRVGELEEKAVEELR----ELVQREPEWTNLLQTTEQPDYDL 684

  Fly   757 DSYCKRGESMFSQLLDIAIQCRDMMAEYRAKLAKEEMLS 795
            :::..:.|.:..:...:.|...|.:...|..|..||..|
Frog   685 ENFVIQAEYLIQERSKVLISLGDSINSLRLALQVEEQAS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	225/329 (68%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	222/324 (69%)
kif2c	NP_001006856.1	KISc_KIF2_like	263..591	CDD:276818	225/329 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	690	1.000	Inparanoid score	I679
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm48886
Panther	1	1.100	-	-	O	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160