DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and zgc:103670

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_005166887.1	Gene:	zgc:103670 / 447926	ZFINID:	ZDB-GENE-040912-111	Length:	747	Species:	Danio rerio

Alignment Length:	814	Identity:	383/814 - (47%)
Similarity:	509/814 - (62%)	Gaps:	99/814 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |.||..|:|||:|||:|.|:|..:|:..:.:||||.|.|:|||||::|:.|.:|||::
Zfish     8 IVVGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLECIFSLNPDV------- 65

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNS 133
              |||.:        :|.:|.                          :.|.|..||..||....:
Zfish    66 --APEEE--------ISLSPV--------------------------TPPPPTPSSVKVNKIPKN 94

  Fly   134 NTTAGGGGGTTTS--TTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAA------ 190
            ..|...|.....|  ...|..|.|.:|....|||.:          |.|...::..|.|
Zfish    95 RRTIAPGRSEIPSRDNRVGSTRARPAQQLQQQQQQQ----------PQPQPESAPPPPAQQPSQP 149

  Fly   191 -QGVATAATTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQ 254
             |....:..||.....:.|:|:.:||||:|:|.||:||.:|.|::|::.  ...|...||:|..|
Zfish   150 TQSQTQSQLTQQQQQNARRKSNCVKEVEKLQEKRERRRLQQQELREKRA--QEVDTTIPNYEILQ 212

  Fly   255 MIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVD 319
            |||:::.:|::.||.....:::|:|.|||||||:::||::.|::|||::|.||:::||||:.|||
Zfish   213 MIRDFRGSLDYRPLTTTDLIEEHRICVCVRKRPLNKKELSVKDLDVITIPSKDVVMVHEPKQKVD 277

  Fly   320 LTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNG 384
            ||::|||..|||||||:|:..|.|||::||:|||:|||:.|||||||||||||||||||||:|:|
Zfish   278 LTRYLENQTFRFDYAFDDSTTNEMVYRFTARPLVETIFDRGMATCFAYGQTGSGKTHTMGGDFSG 342

  Fly   385 KVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQV 449
            |.|||..||||:||:|||:.|..|.|:.::|.|.|:|||||||||||||:.|.||||||||||||
Zfish   343 KNQDCSKGIYALAARDVFLMLKKPNYKKLDLQVYATFFEIYSGKVFDLLNRKAKLRVLEDGKQQV 407

  Fly   450 QVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFID 514
            |||||.|:.|...|:|||||:.||:.|||||||||::||||||||||:||.:|  |:|||||.||
Zfish   408 QVVGLQEREVKCTEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KMHGKFSLID 470

  Fly   515 LAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKS 579
            |||||||.||||||||||:||||||||||||||||||||:...|.|||.||||||||||||||.|
Zfish   471 LAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENS 535

  Fly   580 KTCMIAMISPGLSSCEHTLNTLRYADRVKELVV--KDIVEVCPGGD-TEPIEITDDEEEEELNMV 641
            :|||||.||||::|||:||||||||:||||..:  .||.....||. :||   :...|.:||. |
Zfish   536 RTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQGGGSRSEP---SPTYEVKELT-V 596

  Fly   642 HPH--SHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNM----DLAMLSSLSE 700
            .|:  :..:.||.:|                    .|..:..::....||.    ||.:|...:|
Zfish   597 DPNAVTEGIRPNVNA--------------------INQLDIMDEEWELGNSPQRDDLKLLCEQNE 641

  Fly   701 HEMSDELIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGES 765
            .|:|.:|...|:.:..|...||.|:|.||.|......:|.:.|.|..:|..||||.|||..:.|.
Zfish   642 EEVSPQLFTFHEVVSQLVDMEEQVLEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVDSYSSQLEQ 706

  Fly   766 MFSQLLDIAIQCRDMMAEYRAKLAKEEMLSCSFN 799
            :..|.::|.|:.||.:..:|:.|.:||..|...|
Zfish   707 ILDQKIEILIELRDKVRSFRSALQEEEQASKQIN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	239/329 (73%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	236/324 (73%)
zgc:103670	XP_005166887.1	KISc	236..572	CDD:214526	242/337 (72%)
zgc:103670	XP_005166887.1	KISc_KIF2_like	236..564	CDD:276818	239/329 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I382
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3320
Inparanoid	1	1.050	658	1.000	Inparanoid score	I749
OMA	1	1.010	-	-		QHG45607
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		oto41102
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870