DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and ncd

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	184/744 - (24%)
Similarity:	289/744 - (38%)	Gaps:	209/744 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PEPK--KQATAPMN--LSRNPTQSAIGG--------NLTSRMTMAGNMLNKIQES---------- 114
            |:|.  |:...|:.  |..:..::.:||        |:.:..|..||:|..:...
  Fly     6 PKPSGLKKPQMPIKTVLPTDRIRAGLGGGAAGAGAFNVNANQTYCGNLLPPLSRDLNNLPQVLER 70

  Fly   115 ------QSIPNPIV-----------SSNSVN-TNSNSNTTAGGG-----------GGTTTSTTTG 150
                  .:.|.|:.           |:..:| ...|..|.|...           ||..|.::..
  Fly    71 RGGGARAASPEPMKLGHRAKLRRSRSACDINELRGNKRTAAAPSLPSIPSKVSRLGGALTVSSQR 135

  Fly   151 LQRPRYSQAATGQQQTRIASAV--PNNTLPNPSAAASAG---PAAQGVATAATTQGAGGASTR-- 208
            |.||....:.|       |:||  |..|.|.|.||..|.   ||..|   ||.:.||..|:.:
  Fly   136 LVRPAAPSSIT-------ATAVKRPPVTRPAPRAAGGAAAKKPAGTG---AAASSGAAAAAPKRI 190

  Fly   209 -------RSHALKEVER-LKENREKRRARQAEMK--------------EEKVALMNQDPGNPNWE 251
                   |.|.|.|..: ||...||:.....|::              |.:.:|.|....|   |
  Fly   191 APYDFKARFHDLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDN---E 252

  Fly   252 TAQ-MIREYQSTLEFV---------PLLDGQAVDDHQIT---------VCVRKRP---------- 287
            ..| .::::.:.:|.:         .|.:.||:.:...|         |.:|:|.
  Fly   253 CLQRQVKQHTAKIETITSTLGRTKEELSELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQ 317

  Fly   288 ---------------ISRKEVNRKEIDV---------ISVP------RKDMLIVHEPRSKVDLTK 322
                           :.|||::...:|:         |..|      |......:...|.|:|..
  Fly   318 AAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQS 382

  Fly   323 FLENHK-------FRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGG 380
            .....|       |.||..|:.....:.:::..: ||:::..:|.....|||||||||||:||.|
  Fly   383 IDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVS-PLIQSALDGYNICIFAYGQTGSGKTYTMDG 446

  Fly   381 EFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQK---LRVL 442
                 |.: ..|:.......:|.::...|.......:.|:|.|||:..::||||::||   :|:.
  Fly   447 -----VPE-SVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMA 505

  Fly   443 EDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIH 507
            ::.|..:.|..:||:.|.....:..|:......|.:..|:.|..|||||||.::.|..:.:.|..
  Fly   506 KNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQE 570

  Fly   508 ---GKFSFIDLAGNERGVDTSSADRQTRM-EGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQ 568
               |..:.:||||:|      |....||| |...||:||..|...|.||.::..|:|:|.||||.
  Fly   571 ISVGSINLVDLAGSE------SPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTH 629

  Fly   569 VLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDE 633
            :|..| :|..|||.|...:||.....:.::.:||:|..|..         |        ::|..:
  Fly   630 LLMPS-LGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNS---------C--------KMTKAK 676

  Fly   634 EEEELNMVHPHSHQLHPNSHAPAS-QSNN 661
            ....||           ||.|.:| ||||
  Fly   677 RNRYLN-----------NSVANSSTQSNN 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	108/392 (28%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	107/378 (28%)
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	102/356 (29%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	103/360 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930