DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and Klp68D

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	165/586 - (28%)
Similarity:	254/586 - (43%)	Gaps:	137/586 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 ITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHK-----FRFDYAFNDT 338
            :.|.||.||:|.:|.:.:..:|::        |:..|..|:|...::.:|     |.:|.|::.:
  Fly    20 VQVVVRCRPMSNRERSERSPEVVN--------VYPNRGVVELQNVVDGNKEQRKVFTYDAAYDAS 76

  Fly   339 CDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFV 403
            .....:|.....|||.::.||.....|||||||:|||.||.|.   :..|...||.....:.:::
  Fly    77 ATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGV---RGNDELMGIIPRTFEQIWL 138

  Fly   404 TLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQK-LRVLEDGKQQVQVVGLTEKVVDGVEEVLK 467
            .:|  |......:|..|:.|||..::.|||....| |.|.|.| ..|.|..|.......||:::|
  Fly   139 HIN--RTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERG-SGVYVPNLHAINCKSVEDMIK 200

  Fly   468 LIQHGNAARTSGQTSANSNSSRSHAVFQIVLR---PQGSTKIHGKFSFIDLAGNERGVDT-SSAD 528
            ::|.||..||.|.|:.|.:||||||:|.|.:.   .:.:|...||.:.|||||:||...| :||:
  Fly   201 VMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAE 265

  Fly   529 RQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSS 593
            |  ..|.::||.:|.:|...|.||.:.|.|:|:|.||||::|:|| :|..|||.|||.|.|...:
  Fly   266 R--LKEASKINLALSSLGNVISALAESSPHVPYRDSKLTRLLQDS-LGGNSKTIMIANIGPSNYN 327

  Fly   594 CEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEE------EEEL----NMVHPHSHQL 648
            ...||.|||||.|.|.:            ..:||:..|.::      :||:    .::.|...|
  Fly   328 YNETLTTLRYASRAKSI------------QNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQ- 379

  Fly   649 HPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQ--H 711
             .:.....::....:.|.                             ......||||.|.|.  .
  Fly   380 -RSEKQVTAKKQRVKKPK-----------------------------KETVTKEMSDSLQVSTIE 414

  Fly   712 QAIDD-------------------LQQTEEMVVEYHRTVNATLETFLAESKALY-----NLTNYV 752
            |.::|                   .:..||:  |..|..|:.|...|||.:...     ||.
  Fly   415 QPVEDDSDPEGAESESDKENEAEVAKSNEEL--ERERVENSKLAAKLAELEGQLVRGGKNLL--- 474

  Fly   753 DYDQDSYCKRGESMFSQLLDIA----------------------IQCRDMMAEYRAKLAKEEMLS 795
                |:|.:|...:..:|::||                      |:.|::..|...:|.|.::..
  Fly   475 ----DTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSK 535

  Fly   796 C 796
            |
  Fly   536 C 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	125/338 (37%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	123/334 (37%)
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	126/340 (37%)
		KISc	20..351	CDD:214526	128/359 (36%)
		GBP_C	<479..576	CDD:303769	10/58 (17%)
		coiled coil	547..558	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940