DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and KIF2A

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001091981.1	Gene:	KIF2A / 3796	HGNCID:	6318	Length:	744	Species:	Homo sapiens

Alignment Length:	798	Identity:	380/798 - (47%)
Similarity:	511/798 - (64%)	Gaps:	71/798 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |.:|..|:|||:|||:|.|:|..:|:..:.:||||.|.|:|||||::|::|.:|||:|:.|   :
Human     9 IQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPD---E 70

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNS 133
            ...|.|:   |.|     .|..||              .:|||.:::.    .|:|...:..|..
Human    71 EIEPSPE---TPP-----PPASSA--------------KVNKIVKNRR----TVASIKNDPPSRD 109

  Fly   134 NTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVA-TAA 197
            |...|..            |.|.||                  .|..|::|....:...:: ..|
Human   110 NRVVGSA------------RARPSQ------------------FPEQSSSAQQNGSVSDISPVQA 144

  Fly   198 TTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQST 262
            ..:..|..|.|:|:.:||||:|:|.|||||.:|.|::|::.  .:.|..|||:|...|||:::.:
Human   145 AKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRA--QDVDATNPNYEIMCMIRDFRGS 207

  Fly   263 LEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENH 327
            |::.||.....:|:|:|.|||||||:::||...|::|||::|.||:::||||:.|||||::|||.
Human   208 LDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQ 272

  Fly   328 KFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNG 392
            .|||||||:|:..|.|||::||:|||:||||.|||||||||||||||||||||:|:||.|||..|
Human   273 TFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKG 337

  Fly   393 IYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEK 457
            |||:||:|||:.|..|.|:.:.|.|.|:|||||||||||||:.|.|||||||||||||||||.|:
Human   338 IYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQER 402

  Fly   458 VVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGV 522
            .|..||:|||||..||:.|||||||||::||||||||||:||.:|  |:|||||.|||||||||.
Human   403 EVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFSLIDLAGNERGA 465

  Fly   523 DTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMI 587
            ||||||||||:||||||||||||||||||||:...|.|||.||||||||||||||.|:|||||.|
Human   466 DTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATI 530

  Fly   588 SPGLSSCEHTLNTLRYADRVKEL-VVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHSHQLHPN 651
            |||::|||:||||||||:||||. :....:....|..:.| :::...|.::.:   |...::...
Human   531 SPGMASCENTLNTLRYANRVKEFGISPSDIPFSQGSGSRP-DLSPSYEYDDFS---PSVTRVKEL 591

  Fly   652 SHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQAIDD 716
            :..|.:..:.:  |..||....|.:.........:....||.:|...:|.|:|.:|...|:|:..
Human   592 TVDPTAAGDVR--PIMHHPPNQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQ 654

  Fly   717 LQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLLDIAIQCRDMM 781
            :.:.||.|||.||.|......:|.:.|||..:|..||||.|||..:.|::..|.:||..:.||.:
Human   655 MVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKV 719

  Fly   782 AEYRAKLAKEEMLSCSFN 799
            ..:||.|.:||..|...|
Human   720 KSFRAALQEEEQASKQIN 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	241/329 (73%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	238/324 (73%)
KIF2A	NP_001091981.1	KISc	223..559	CDD:214526	244/337 (72%)
KIF2A	NP_001091981.1	KISc_KIF2_like	223..551	CDD:276818	241/329 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	488	1.000	Domainoid score	I386
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3320
Inparanoid	1	1.050	671	1.000	Inparanoid score	I740
Isobase	1	0.950	-	0	Normalized mean entropy	S2059
OMA	1	1.010	-	-		QHG45607
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm41668
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820