DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and unc-104

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	167/565 - (29%)
Similarity:	247/565 - (43%)	Gaps:	139/565 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 ITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHE--PRSKVDLTKFLENHKFRFDYAF------ 335
            :.|.||.||.:.:|:.|:...:|.:......|.:.  |.:..|..|     :|.|||::
  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVK-----RFNFDYSYWSHDHH 63

  Fly   336 -NDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAK 399
             .|....:||||...:.:::..|:|.....|||||||:||::||    .|:.::.:.||..|..|
  Fly    64 DADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTM----MGRQEEQQEGIIPMICK 124

  Fly   400 DVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQK--LRVLEDGKQQVQVVGLTEKVVDGV 462
            |:|..:.......:...|..|:.|||..:|.|||:.|.|  |||.|.......|..|::..|...
  Fly   125 DLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDY 189

  Fly   463 EEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIV-------LRPQGSTKIHGKFSFIDLAGNER 520
            :::..||..||.|||...|:.|..||||||||.|.       |....:|:...|.|.:||||:||
  Fly   190 QDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSER 254

  Fly   521 GVDTSSADRQTRM-EGAEINKSLLALKECIRALG---------KQSAHLPFRVSKLTQVLRDSFI 575
            ...|.:  :.||: |||.|||||..|.:.|.||.         |::..:|:|.|.||.:||:: :
  Fly   255 ADSTGA--KGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLREN-L 316

  Fly   576 GEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIV--------------EVCPGGDTEP 626
            |..|||.|||.|||...:.:.||:|||||||.|::|.|.:|              |:....|...
  Fly   317 GGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLK 381

  Fly   627 IEITDDEEEEELNMVHPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMD 691
            .|..:.:||:||.                              ...||.:...:.|:||:...|
  Fly   382 AEGIEVQEEDELT------------------------------KSTVIKSPTKSRNRNGSTTEM- 415

  Fly   692 LAMLSSLSEHEMSDELIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQ 756
                                 |:|.||.:|:::.|    :|.|.|..|
  Fly   416 ---------------------AVDQLQASEKLIAE----LNETWEEKL----------------- 438

  Fly   757 DSYCKRGESMFSQLLDIAIQCRDMMAEYRAKLAKEEMLSCSFNSP 801
                ||.|       :|.:|...:.||....: ||:.::....||
  Fly   439 ----KRTE-------EIRVQREAVFAEMGVAV-KEDGITVGVFSP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	129/356 (36%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	127/352 (36%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	132/365 (36%)
		KISc	3..358	CDD:214526	132/365 (36%)
		Kinesin_assoc	355..498	CDD:292801	35/202 (17%)
		FHA	475..574	CDD:238017
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940