DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and neb

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	157/566 - (27%)
Similarity:	234/566 - (41%)	Gaps:	142/566 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 STRRSHALKEVERLK-ENREKR-RARQ----------AEMKEEKVAL------------MNQDPG 246
            ||..|...|:|...: |:||.| |..|          .:.|.:..||            .|..||
  Fly    23 STPASEMRKKVLMTRAEDREHRDRPEQLLNTAFSGSTPQPKPKPTALNACYTPSSLYRNANSTPG 87

  Fly   247 NPNW-----ETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEI-DVISVPR 305
            ....     .:....:|..|.:|....:.    ::..:.|.||.||::..|..|.:: :|:.|..
  Fly    88 RAKTPGTGKSSCSRTKERDSLMESCLSVS----EESNMIVAVRVRPLNALECTRGQVTNVVQVHG 148

  Fly   306 KDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCD--------NAMVYKYTAKPLVKTIFEGGMA 362
            ....:..:..|..|.:..: .|.|.:|..:. :||        .|.|::.||:||:.|.|||..|
  Fly   149 NSNELTVQAGSSADASAGV-THFFSYDQVYY-SCDPERKNFACQAKVFEGTARPLIDTAFEGYNA 211

  Fly   363 TCFAYGQTGSGKTHTMGG-------EFNGKVQDCKNGIYAMAAKDVFVTLN-MPRYRAMNLVVSA 419
            ..||||||||||:::|.|       ..:|.....:.||......::|..:. :...:.:.:.|..
  Fly   212 CLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEV 276

  Fly   420 SFFEIYSGKVFDLLS--------------------DKQKLRVLEDGKQQVQVVGLTEKVVDGVEE 464
            |:||||:.|:.||||                    .:..|:|.|.......||.|:...||....
  Fly   277 SYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSA 341

  Fly   465 VLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHG-------------------KF 510
            :...:..||:.|.:..|:.|..|||||::|.|||.....:...|                   |.
  Fly   342 LRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKI 406

  Fly   511 SFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRAL--------------GKQSAHLPF 561
            |.:||||:|| :..|.::.:...||..||||||.|.:.|.||              |..|..:|:
  Fly   407 SLVDLAGSER-ISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPY 470

  Fly   562 RVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYA-------DRVK------ELVVK 613
            |.|.||.:||:: :|..|||.|:|.|||.....:.||.|||||       :|||      :.:::
  Fly   471 RESVLTWLLREN-LGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIR 534

  Fly   614 DI-VEV---------------CPGGDTEP------IEITDDEEEEE 637
            |: .||               ..|....|      ||.:.||.|.|
  Fly   535 DLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	124/406 (31%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	124/407 (30%)
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	126/409 (31%)
		KISc	120..525	CDD:214526	126/408 (31%)
		Kinesin_assoc	524..657	CDD:292801	11/57 (19%)
		FHA	634..740	CDD:238017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030