DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and Kif2b

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001005874.2	Gene:	Kif2b / 287624	RGDID:	1359248	Length:	664	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	318/786 - (40%)
Similarity:	442/786 - (56%)	Gaps:	166/786 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQHA 70
            ||..|.|:|:|.|:|:|||..||:....:||||.|:|..|||::||:.:|.|||.|        |
  Rat    28 VGICVAIQRSDKRIHLAVVTEINRENSWVTVEWVEKGVKKGKKIELETVLLLNPAL--------A 84

  Fly    71 APEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNSNT 135
            :.|.::        ||.|.:                           |..::.:.::
  Rat    85 STEHQR--------SRRPLR---------------------------PVSVIPATAI-------- 106

  Fly   136 TAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVATAATTQ 200
                 |...|:|......|..::..:|..||.:   :|:|            |...
  Rat   107 -----GDQRTATKWIAMIPHRNETPSGDSQTLV---IPSN------------PCLM--------- 142

  Fly   201 GAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQSTLEF 265
                 ..::|..|:|:|:|::.|||||..|.|::..:...:|  .||||:||.:||.||:..|:.
  Rat   143 -----KRKKSPCLREIEKLQKQREKRRRLQLEIRARRALDIN--TGNPNFETMRMIEEYRRHLDS 200

  Fly   266 VPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFR 330
            ..:...:..:||:|.|||||||::.:|...|::|:|::|..::::|||.:.|||||::|||..|.
  Rat   201 SKMSRLEPPEDHRICVCVRKRPLNERETTMKDLDIITIPSHNVVMVHESKQKVDLTRYLENQTFC 265

  Fly   331 FDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYA 395
            ||:||:||..|.:||::||:|||::||..|||||||||||||||||||||.|:||.|:|..||||
  Rat   266 FDHAFDDTASNELVYQFTARPLVESIFRKGMATCFAYGQTGSGKTHTMGGAFSGKAQECSKGIYA 330

  Fly   396 MAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVD 460
            :.|:|||:.|..|.|..:.|.|..:|||||.|||:|||:.|:||:|||||.||:|||||.|:.|.
  Rat   331 LVAQDVFLLLRTPAYEKLELKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEQEVG 395

  Fly   461 GVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTS 525
            .|||||.|::.||:.|||||||.|::|||||||||::|:..|  |:|||||.:||||||||.||:
  Rat   396 CVEEVLNLVELGNSCRTSGQTSVNAHSSRSHAVFQLILKCGG--KLHGKFSLVDLAGNERGADTA 458

  Fly   526 SADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPG 590
            .|.|:.::|||||||||||||||||||||..:|.|||.|||||||||||||:.|.|||||.||||
  Rat   459 KATRKRQLEGAEINKSLLALKECIRALGKNKSHTPFRASKLTQVLRDSFIGQNSYTCMIATISPG 523

  Fly   591 LSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHSHQLHPNSHAP 655
            ::|||:||||||||:|||||.::                           ..|:
  Rat   524 MTSCENTLNTLRYANRVKELALE---------------------------ARPY----------- 550

  Fly   656 ASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQAIDDLQQT 720
                    .|..|.....:.|.|.|:.|  :....|:..:.::.:.|..:.        |:|..|
  Rat   551 --------PPTDHEMPLTLENGNTNSEK--SLQKDDIIQIPTVQKEEEKES--------DELTST 597

  Fly   721 EEMVVEYHRT---VNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLLDIAIQCRDMMA 782
            :|....:.|:   ..|..||  ||.         |:.|.| :|      .:|.|.|..|...::.
  Rat   598 KEPAASWSRSGPWWEAIQET--AEG---------VNCDVD-FC------IAQSLSILEQKIGVLT 644

  Fly   783 EYRAKL 788
            |.:.||
  Rat   645 EIQKKL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	213/329 (65%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	210/324 (65%)
Kif2b	NP_001005874.2	KISc_KIF2_like	213..541	CDD:276818	213/329 (65%)
		Kinesin	219..542	CDD:278646	210/324 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..607		5/31 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I378
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45607
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm45791
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790