DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and klp-7

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001022677.1	Gene:	klp-7 / 176511	WormBaseID:	WBGene00002219	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	671	Identity:	308/671 - (45%)
Similarity:	407/671 - (60%)	Gaps:	66/671 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVE 67
            |:.||..|:|||:|||:|.||:|.:..:|: ..|||||:|||||||..|:.:|||||.|.
Worm    59 MLVVGMHVEIKRSDGRIHGAVIAEVKSNGR-FMVEWYEKGETKGKESSLEELLTLNPSLQ----- 117

  Fly    68 QHAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSN 132
               ||:|    |.|    ..|.|.      |.:.:.|.|..|.| .:||:   |:.........:
Worm   118 ---APKP----TPP----PQPPQK------TLQASTAVNRQNGI-HAQSM---ILDDEDTFLLDH 161

  Fly   133 SNTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIA----SAVPNNTLPNPSAAASAGPAAQGV 193
            .|.....|....       :||  :.|.|.....|:|    ..:|....|:|...|:..|.:...
Worm   162 INMIPAKGASAN-------KRP--TGAFTQHVPVRMAPPSEKPLPTRRAPSPKEDAAPAPKSTRT 217

  Fly   194 ATAATTQGAGGASTRRSHALKEVERLK-----------ENREKRR-----ARQAEMKEEKVALMN 242
            ..|........|.|...|..:....:.           .|...:|     ||....|....:...
Worm   218 TAAFKPDLDSTAITVPKHTARRTVVVAPAPAPVPAPPIANMTSQRAPSPVARVPSPKNVPRSYPQ 282

  Fly   243 QD--PGNPNWETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPR 305
            ||  |.|.|:..|:|||.|::.:::.||.....|::::|:|||||||:::||:.:.|:|||::|.
Worm   283 QDVQPSNGNFAFAEMIRNYRAQIDYRPLSMFDGVNENRISVCVRKRPLNKKELTKAEVDVITIPS 347

  Fly   306 KDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQT 370
            :|:.|:|:|:::|||||:|:|.||||||:|::..:|.:||::||.|||||:|:.|.|||||||||
Worm   348 RDITILHQPQTRVDLTKYLDNQKFRFDYSFDEYANNELVYRFTAAPLVKTVFDNGTATCFAYGQT 412

  Fly   371 GSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSD 435
            ||||||||||:|:||.|:...||||:.|:|||..|..|:||..:|.|..:|||||..|.:|||:|
Worm   413 GSGKTHTMGGDFSGKKQNASMGIYALTARDVFRMLEQPQYRRKDLSVHCAFFEIYGTKTYDLLND 477

  Fly   436 KQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRP 500
            |.:||||||..|:||||||.|:.....::||:||..|...||:|.||||:|||||||:|||:||
Worm   478 KAELRVLEDKMQKVQVVGLKEEQAHNEQDVLELINKGTLVRTAGTTSANANSSRSHAIFQIILR- 541

  Fly   501 QGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSK 565
            ||. |:.||||.|||||||||.||...||.||.|||.||.||||||||||.:.:.|:|:|||.||
Worm   542 QGK-KVWGKFSLIDLAGNERGQDTRECDRDTRKEGANINTSLLALKECIRGMARNSSHVPFRQSK 605

  Fly   566 LTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTE----P 626
            ||.|||||||||||:|.||:|||||:||.:||||||||||||||:......|..|..|.|    |
Worm   606 LTMVLRDSFIGEKSRTVMISMISPGISSSDHTLNTLRYADRVKEMGTDGSGEATPIRDEELFLPP 670

  Fly   627 IEITDDEEEEELNMVHPHSHQ 647
            .....|||.:|  ||....|:
Worm   671 SADKSDEEYDE--MVEKQEHR 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	209/329 (64%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	206/324 (64%)
klp-7	NP_001022677.1	KISc_KIF2_like	320..648	CDD:276818	209/329 (64%)
klp-7	NP_001022677.1	Kinesin	326..649	CDD:278646	206/324 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156140
Domainoid	1	1.000	426	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I697
Isobase	1	0.950	-	0	Normalized mean entropy	S2059
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm14692
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880