Protein Alignment Klp10A and Kif2a

DIOPT Version :10

• Sequence 1: NP_572687.1
• Gene: Klp10A / 32049
• FlyBaseID: FBgn0030268
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001361656.1
• Gene: Kif2a / 16563
• MGIID: 108390
• Length: 743
• Species: Mus musculus
• Alignment Length: 820
• Identity: 384/820 - (46%)
• Similarity: 502/820 - (61%)
• Gaps: 116/820 - (14%)

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |.:|..|:|||:|||:|.|:|..:|:..:.:||||.|.|:|||||::|::|.:|||:|:.|
Mouse     9 IQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPD---- 69

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSS--NSVNTNS 131
                                                    ..|:.|..:|.|..||  |.:..|.
Mouse    70 ----------------------------------------EDIEPSPELPPPSSSSKVNKIVKNR 94

  Fly   132 NSNTTAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVA-T 195
            .:............:...|..|.|.||                  ||..|::|....:...:: .
Mouse    95 RTVAAVKNDPPPRDNRVVGSARARPSQ------------------LPEQSSSAQQNGSVSDISPV 141

  Fly   196 AATTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQ 260
            .|..:..|..|.|:|:.:||||:|:|.|||||.:|.|::|::.  .:.|..|||:|...|||:::
Mouse   142 QAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRA--QDVDATNPNYEIMCMIRDFR 204

  Fly   261 STLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLE 325
            .:|::.||.....:|:|:|.|||||||:::||...|::|||::|.||:::||||:.|||||::||
Mouse   205 GSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLE 269

  Fly   326 NHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCK 390
            |..|||||||:|:..|.|||::||:|||:||||.|||||||||||||||||||||:|:||.|||.
Mouse   270 NQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCS 334

  Fly   391 NGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLT 455
            .||||:||:|||:.|..|.|:.:.|.|.|:|||||||||||||:.|.|||||||||||||||||.
Mouse   335 KGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQ 399

  Fly   456 EKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNER 520
            |:.|..||:|||||..||:.|||||||||::||||||||||:||.:|  |:|||||.||||||||
Mouse   400 EREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFSLIDLAGNER 462

  Fly   521 GVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIA 585
            |.||||||||||:||||||||||||||||||||:...|.|||.||||||||||||||.|:|||||
Mouse   463 GADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIA 527

  Fly   586 MISPGLSSCEHTLNTLRYADRVKELVV--KDIVEVCPGG---DTEPIEITDD-----EEEEELNM 640
            .||||::|||:||||||||:||||..:  .||.....||   |..|....||     ...:||.:
Mouse   528 TISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQGGGSRPDLSPSYDYDDFSPSITRVKELTV 592

  Fly   641 VHPHSHQLHPNSHAPASQ-----------SNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAM 694
            ....:..:||..|.|.||           |:.||.                          ||.:
Mouse   593 NPAAAGDVHPIMHHPPSQIDDLETQWGVGSSPQRD--------------------------DLKL 631

  Fly   695 LSSLSEHEMSDELIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSY 759
            |...:|.|:|.:|...|:|:..:.:.||.|||.||.|......::.:.|||..:|..||||.|||
Mouse   632 LCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSY 696

  Fly   760 CKRGESMFSQLLDIAIQCRDMMAEYRAKLAKEEMLSCSFN 799
            ..:.|::..|.:||..:.||.:..:||.|.:||..|...|
Mouse   697 ATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQIN 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_572687.1	KISc_KIF2_like	278..608	CDD:276818	241/329 (73%)
Kif2a	NP_001361656.1	KISc_KIF2_like	222..550	CDD:276818	241/329 (73%)