DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klp10A and KIF2C

DIOPT Version :9

Sequence 1:NP_001285109.1 Gene:Klp10A / 32049 FlyBaseID:FBgn0030268 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_006836.2 Gene:KIF2C / 11004 HGNCID:6393 Length:725 Species:Homo sapiens


Alignment Length:805 Identity:353/805 - (43%)
Similarity:481/805 - (59%) Gaps:109/805 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 GQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQHAA 71
            |.::||:|::|.:|.|.|..:|....|::|||.|.|.|||||::.|.:..:||||:|        
Human    14 GLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQ-------- 70

  Fly    72 PEPKKQATAPMNLSRN-PTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNSNT 135
                   ..|::...| |.|.    |:|.:.....::.:|      ||.|   ..|:.:.|...:
Human    71 -------LLPLHPKDNLPLQE----NVTIQKQKRRSVNSK------IPAP---KESLRSRSTRMS 115

  Fly   136 TAGGGGGTTTSTTTGLQRPRYSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVATAATTQ 200
            |......|.......::.|   .||..::|..:..| |.    .||..|.|....:.|:.....|
Human   116 TVSELRITAQENDMEVELP---AAANSRKQFSVPPA-PT----RPSCPAVAEIPLRMVSEEMEEQ 172

  Fly   201 -----GAGGAS-----TRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQM 255
                 |:..|:     .|:|..:||||::|..||:::|:.:||:.::.  ...|...||||.|:|
Human   173 VHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRA--QEYDSSFPNWEFARM 235

  Fly   256 IREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDL 320
            |:|:::|||..||.....:::|:|.|||||||::::|:.:|||||||:|.|.:|:||||:.||||
Human   236 IKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDL 300

  Fly   321 TKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGK 385
            ||:|||..|.||:||::|..|.:||::||:|||:||||||.|||||||||||||||||||:.:||
Human   301 TKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGK 365

  Fly   386 VQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQ 450
            .|:...||||||::|||:..|.|.||.:.|.|..:|||||:||:||||:.|.|||||||||||||
Human   366 AQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQ 430

  Fly   451 VVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDL 515
            ||||.|.:|:..::|:|:|..|:|.||||||.||||||||||.|||:||.:|  ::|||||.:||
Human   431 VVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRAKG--RMHGKFSLVDL 493

  Fly   516 AGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSK 580
            ||||||.|||||||||||||||||||||||||||||||:..||.|||.||||||||||||||.|:
Human   494 AGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSR 558

  Fly   581 TCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHS 645
            |||||.||||:||||:||||||||||||||                               .|||
Human   559 TCMIATISPGISSCEYTLNTLRYADRVKEL-------------------------------SPHS 592

  Fly   646 HQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQ 710
               .|:..........:....|  :||:|            .||:      |..|.|:|.::...
Human   593 ---GPSGEQLIQMETEEMEACS--NGALI------------PGNL------SKEEEELSSQMSSF 634

  Fly   711 HQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLLDIAI 775
            ::|:..:::.||..:|..:.:......:|    .|..:|...|||.:::..:.||..:|......
Human   635 NEAMTQIRELEEKAMEELKEIIQQGPDWL----ELSEMTEQPDYDLETFVNKAESALAQQAKHFS 695

  Fly   776 QCRDMMAEYRAKLAKEEMLSCSFNS 800
            ..||::...|..:..||..|...:|
Human   696 ALRDVIKALRLAMQLEEQASRQISS 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp10ANP_001285109.1 KISc_KIF2_like 278..608 CDD:276818 234/329 (71%)
Kinesin 284..609 CDD:278646 231/324 (71%)
KIF2CNP_006836.2 Globular. /evidence=ECO:0000255 2..254 80/277 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..116 6/35 (17%)
Microtubule tip localization signal 98..101 1/8 (13%)
Negative regulator of microtubule-binding. /evidence=ECO:0000250 207..238 11/32 (34%)
KISc_KIF2_like 258..586 CDD:276818 234/329 (71%)
Nuclear localization signal. /evidence=ECO:0000255 415..418 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140809
Domainoid 1 1.000 488 1.000 Domainoid score I386
eggNOG 1 0.900 - - E2759_KOG0246
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 671 1.000 Inparanoid score I740
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D202066at33208
OrthoFinder 1 1.000 - - FOG0001531
OrthoInspector 1 1.000 - - otm41668
orthoMCL 1 0.900 - - OOG6_100492
Panther 1 1.100 - - O PTHR24115
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X866
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.760

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