DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and kif24

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_031750808.1	Gene:	kif24 / 101731767	XenbaseID:	XB-GENE-855671	Length:	1371	Species:	Xenopus tropicalis

Alignment Length:	772	Identity:	258/772 - (33%)
Similarity:	355/772 - (45%)	Gaps:	186/772 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ITVEWYERGETKGKEVELDAILTLNPELMQD--------TVEQHAAPEPKKQATAPMNLSRNPTQ 90
            ||::.|.|               |..|.|:|        .:.|..|.|.||:        |.|.|
Frog    72 ITMKDYSR---------------LGVERMEDRKRLFQLIQIIQSVAEEDKKE--------RTPLQ 113

  Fly    91 -SAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNSNTTAGGGGGTTTSTTTGLQRP 154
             ..:...|....:.|...|......:.....|..|...:..|.:|.      |.:.||.:... |
Frog   114 PGCVYPQLLHDRSGARRQLQFDASIEETLGTIAQSEFCHIRSMNNP------GDSVSTASPAD-P 171

  Fly   155 RYSQ--AATGQQQTRIASAVPNN--TLPNPSAAASAGPAAQGVATAATTQGAGGASTRRSHAL-- 213
            ||.:  .::|.:.....||...|  |||:..:|..            .:.|......|.:|.|
Frog   172 RYCRNIHSSGTEADTTCSAKTQNTKTLPHRGSAPD------------LSDGEIPIIHRVAHVLGY 224

  Fly   214 -----KEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQSTLEFVPLLDGQA 273
                 :...||....:||                      .|.....||
Frog   225 NYGVPQTCRRLDPTEKKR----------------------PWTETDRIR---------------- 251

  Fly   274 VDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDT 338
                   |||||||:|.:|..|.|::|:|...|..:.::|.:..|:|.:::..|.|.||..|::|
Frog   252 -------VCVRKRPLSSREERRGEVNVVSAEEKGTITIYERKEAVNLKEYILQHAFYFDEVFSET 309

  Fly   339 CDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKN-GIYAMAAKDVF 402
            ..|..||..||.||::.:|.||.||||||||||:||||||.|       ..|| |:||:||||:|
Frog   310 FTNQDVYMRTAYPLIQHVFNGGNATCFAYGQTGAGKTHTMIG-------TQKNPGLYALAAKDIF 367

  Fly   403 VTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLK 467
            ..|...:.:: :..|..||:|||.|:::|||:::::|...||||..||:.||.|..|..||.:|:
Frog   368 QQLATVQLKS-DCKVWISFYEIYCGQLYDLLNERKRLYAREDGKHVVQIAGLREVQVSSVELLLE 431

  Fly   468 LIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTR 532
            :|..|:..|::|.:..||:|||||||.||.::...:.|: |:.|||||||:||..|...:|:||:
Frog   432 MILKGSRERSTGASGVNSDSSRSHAVIQIQMKNSKNRKL-GRISFIDLAGSERASDAKESDKQTK 495

  Fly   533 MEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHT 597
            :||||||:||||||||||||.::.||.|||.|||||||:||||| .|||||||.:||...:.|||
Frog   496 LEGAEINQSLLALKECIRALDQEQAHTPFRQSKLTQVLKDSFIG-NSKTCMIANVSPSHIATEHT 559

  Fly   598 LNTLRYADRVKEL----------------VVKDIVEVCPGGDTEPIEITDDEEEEELNMVH-PHS 645
            |||||||||||||                |....|:..|.|..:.|    ..::.:|...| ..|
Frog   560 LNTLRYADRVKELKRGTTSHSAHGRPAACVSPKRVQNAPAGSGDKI----SPKKVKLGQQHISAS 620

  Fly   646 HQ---------LHPN----SHAP--ASQSN----NQRAPASHHSGAV---IHNNNNNNNKNGNAG 688
            ||         .||.    |..|  .|:|:    |.|....:|...|   :.:..:...|||
Frog   621 HQAKSKSCPSVFHPTIIPLSSTPKYCSKSSTVKENARDAGLNHMTPVKGTLRSGASGKKKNG--- 682

  Fly   689 NMDLAMLSSLSEHEMSDEL--IVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESK 743
                         :.||.|  |.|.....:.:.|.||       .|...|.|:...|
Frog   683 -------------KTSDGLYPIFQSPTTSNTETTCEM-------RNIKRENFVGTQK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	171/330 (52%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	169/325 (52%)
kif24	XP_031750808.1	SAM_KIF24-like	41..99	CDD:188940	8/41 (20%)
kif24	XP_031750808.1	KISc_KIF2_like	249..570	CDD:276818	173/353 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010