DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp10A and kif2a

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_002934245.2	Gene:	kif2a / 100379688	XenbaseID:	XB-GENE-951755	Length:	745	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	384/808 - (47%)
Similarity:	509/808 - (62%)	Gaps:	89/808 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPELMQDTVEQ 68
            |.:|..|:|||:|||:|.|:|..:|:..:.|||||.|.|:|||||::|::|.:|||:|..|. |.
Frog     8 IHIGIYVEIKRSDGRIHQAMVTSLNEDSESITVEWIENGDTKGKEIDLESIFSLNPDLAPDE-EI 71

  Fly    69 HAAPEPKKQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLNKIQESQSIPNPIVSSNSVNTNSNS 133
            ...||.....|        ||                ..:|||.:::....|:.:    .|.:..
Frog    72 DPGPEMPPPPT--------PT----------------TKVNKIVKNRRTVAPVKN----ETPARD 108

  Fly   134 NTTAGGGGGTTTSTTTGLQRPR--YSQAATGQQQTRIASAVPNNTLPNPSAAASAGPAAQGVATA 196
            |..|        :.::...||.  ..|:|:.||...::...|:.            |..:..
Frog   109 NRVA--------AVSSARARPSQPIEQSASAQQNGSVSDISPDQ------------PGKKDF--- 150

  Fly   197 ATTQGAGGASTRRSHALKEVERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQS 261
                  |..|.|:|:.:||||:|:|.|||||.:|.|::|:|.  .:.|..|||:|...||::::.
Frog   151 ------GPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKKA--QDVDATNPNYEIMCMIKDFRG 207

  Fly   262 TLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLEN 326
            :|::.||.....:|:|:|.|||||||:::||...|::|||::|.||:::||||:.|||||:||||
Frog   208 SLDYRPLTTADTIDEHRICVCVRKRPLNKKENTVKDLDVITIPSKDVVMVHEPKQKVDLTRFLEN 272

  Fly   327 HKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKN 391
            ..|||||||::|..|.|||::||:|||:||||.|||||||||||||||||||||:|:||.|||..
Frog   273 QTFRFDYAFDETAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSK 337

  Fly   392 GIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTE 456
            ||||:||:|||..|..|.|:.:.|.|.|:|||||||||||||:.|.|||||||||||||||||.|
Frog   338 GIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQE 402

  Fly   457 KVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERG 521
            :.|..||:|||||:.||:.|||||||||::||||||||||:||.:|  |:|||||.|||||||||
Frog   403 REVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKG--KLHGKFSLIDLAGNERG 465

  Fly   522 VDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAM 586
            .||||||||||:||||||||||||||||||||:...|.|||.||||||||||||||.|:|||||.
Frog   466 ADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIAT 530

  Fly   587 ISPGLSSCEHTLNTLRYADRVKELVV--KDIVEVCPGG---DTEPIEITDD-----EEEEELNMV 641
            ||||::|||:||||||||:||||..:  .||......|   |..|....||     ...:||.:.
Frog   531 ISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQGSGSRSDLSPSYEYDDFSPTLTRVKELTVD 595

  Fly   642 HPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDE 706
            ...:..|.|..|...:|.::..|         :....::..::      ||.:|...:|.|:|.:
Frog   596 PSAAGDLRPMIHHAPNQLDDVEA---------LWGVGSSPQRD------DLKLLCEQNEEEVSPQ 645

  Fly   707 LIVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLL 771
            |...|:|:..:.:.||.|||.||.|......:|.:.|.|..:|..||||.|||..:.|::..|.:
Frog   646 LFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVDSYATQLEAILEQKI 710

  Fly   772 DIAIQCRDMMAEYRAKLAKEEMLSCSFN 799
            ||..:.||.:..:||.|.:||..|...|
Frog   711 DILTELRDKVKSFRAALQEEEQASKQIN 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	242/329 (74%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	239/324 (74%)
kif2a	XP_002934245.2	KISc_KIF2_like	224..552	CDD:276818	242/329 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3320
Inparanoid	1	1.050	690	1.000	Inparanoid score	I679
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm48886
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3177
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090