DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp10A and LOC100333835

DIOPT Version :9

Sequence 1:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_021334897.1	Gene:	LOC100333835 / 100333835	-ID:	-	Length:	761	Species:	Danio rerio

Alignment Length:	858	Identity:	352/858 - (41%)
Similarity:	483/858 - (56%)	Gaps:	181/858 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITVGQSVKIKRTDGRVHMAVVAVINQSGKCITVEWYERGETKGKEVELDAILTLNPE-------- 60
            |.:|..|:|||:|||:|.|:|..:|.....:||||.|.|:||||||:|:::.:|||:
Zfish     8 IQIGIYVEIKRSDGRIHQAMVTSLNDHNDSVTVEWIENGDTKGKEVDLESVFSLNPDVAPEEEIL 72

  Fly    61 --------LMQDTVEQHAAPEPK-KQATAPMNLSRNPTQSAIGGNLTSRMTMAGNMLN------- 109
                    ||......:..|:.| ::|.||:. |..|.:.       :|.|:...|::
Zfish    73 QSPETPPPLMSSAARPNKIPQSKNRRAVAPVK-SETPAKD-------NRGTLIIIMIHGRRWVCF 129

  Fly   110 -----------------KIQESQSIPNPIVSSN---SVNTNSNSNTTAGGGGGTTTSTTTGLQRP 154
                             .::.:...||..|:.:   ||.            ||||        |.
Zfish   130 GFLCFCTCPLAVVLKCVYVESACVCPNVCVTCDLPYSVT------------GGTT--------RA 174

  Fly   155 RYSQAATGQQQTRIASAVPNN----TLPNPSAAASAGPAAQGVATAATTQGAGGASTRRSHALKE 215
            |.||    |.:...|.|.|.|    ||...:|                        .|:|:.:||
Zfish   175 RPSQ----QTEPPAAPAPPMNIQQQTLQQQNA------------------------RRKSNCVKE 211

  Fly   216 VERLKENREKRRARQAEMKEEKVALMNQDPGNPNWETAQMIREYQSTLEFVPLLDGQAVDDHQIT 280
            ||:|:|.|||||.:|.|::|::.  ...|...||:|...|||:::::|::.||.....::||:|.
Zfish   212 VEKLQEKREKRRLQQQELREKRA--QEVDTTTPNYEIMCMIRDFRASLDYRPLTTADLIEDHRIC 274

  Fly   281 VCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVY 345
            ||||.||:::||::.|::|||::|.||:::||||:.|||||::|||..|||||||:||..|.|||
Zfish   275 VCVRTRPLNKKELSMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDTSTNEMVY 339

  Fly   346 KYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRY 410
            ::||:|||:|:||.|||||||||||||||||||||:|:||.|||..||||:||:|||:.|..|.|
Zfish   340 RFTARPLVETVFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPIY 404

  Fly   411 RAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNA- 474
            :.::|.|.::||||||||                       |.:...|::      ..:|.|:.
Zfish   405 KKLDLQVFSTFFEIYSGK-----------------------VSVHTSVLN------SCVQLGDVC 440

  Fly   475 -----ARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRME 534
                 .|||||||||::||||||||||::|.:|  |:|||||.|||||||||.||||||||||:|
Zfish   441 VCVCLCRTSGQTSANAHSSRSHAVFQIIVRRRG--KMHGKFSLIDLAGNERGADTSSADRQTRLE 503

  Fly   535 GAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLN 599
            |||||||||||||||||||:...|.|||.||||||||||||||.|:|||||.||||::|||:|||
Zfish   504 GAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLN 568

  Fly   600 TLRYADRVKELVV--KDIVEVCPGGDTEPIEITDDEEE----EELNM---VHPHSH---QLHPNS 652
            |||||:||||..:  .||.....||....:..||:..:    :||.:   |.|.|.   ||....
Zfish   569 TLRYANRVKEFGISPSDIPFSQSGGARSDLSPTDEYADSCRMKELVLDPGVLPESRVGSQLEVLE 633

  Fly   653 HAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQAIDDL 717
            ......|:.||.                          ||.:|...:|.|:|.:|...|:.:..|
Zfish   634 AQWGMGSSPQRD--------------------------DLKLLCEQNEEEVSPQLFTFHEVVSQL 672

  Fly   718 QQTEEMVVEYHRTVNATLETFLAESKALYNLTNYVDYDQDSYCKRGESMFSQLLDIAIQCRDMMA 782
            .:.||.|:|.||.|......:|.:.|.|..:|..||||.:|:..:.|.:..|.:|:.::.||.:.
Zfish   673 VEMEEQVLEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVESFATQLEQILDQKIDVLVELRDKVK 737

  Fly   783 EYRAKLAKEEMLS 795
            .:|:.|.:||..|
Zfish   738 SFRSALQEEEQAS 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	208/335 (62%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	205/330 (62%)
LOC100333835	XP_021334897.1	KISc_KIF2_like	272..577	CDD:276818	208/335 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010