Protein Alignment Hsp60A and CCT6A

DIOPT Version :10

• Sequence 1: NP_511115.2
• Gene: Hsp60A / 32045
• FlyBaseID: FBgn0015245
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001753.1
• Gene: CCT6A / 908
• HGNCID: 1620
• Length: 531
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 129/583 - (22%)
• Similarity: 231/583 - (39%)
• Gaps: 119/583 - (20%)

  Fly    33 RAMMLQGVDV-----LADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAK 92
            ||.....|::     |.|.:...:||||...::....|..|:||||..:...:::    |:..|.
Human    15 RAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQI----QHPTAS 75

  Fly    93 LVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLK--TMS 155
            |:..||...::..|||||:..::...:.|:....||:|.:|..|..|...|.|.....|:  .:|
Human    76 LIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVS 140

  Fly   156 RPVSTPEEIAQVA--TISANGDQAIGNLISEAMKKVGRDGVITVK----------------DGKT 202
            |.:.. |.:..||  ::.......:.::::||:.    |.::.:|                ..|:
Human   141 REMDR-ETLIDVARTSLRTKVHAELADVLTEAVV----DSILAIKKQDEPIDLFMIEIMEMKHKS 200

  Fly   203 LTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLL-------LSEKKISS---VQSIIPAL 257
            .|| ..:|.|:..|.|...|       ..|...:||.:|       ..:.:::|   .:|.....
Human   201 ETD-TSLIRGLVLDHGARHP-------DMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEERE 257

  Fly   258 ELANAQR-------KPLVIIAEDIDGEA-LSTLVVNRLKIG-LQVAAVKAPGFGDNRKSTLTDM- 312
            :|..|:|       |.::.:...:.|:: ...:|:|:..|. ..:.|:...|....|::...:|
Human   258 KLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNME 322

  Fly   313 --AIASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIE 375
              .:|.||:.      |...:|:....||..|.|                             .|
Human   323 RLTLACGGVA------LNSFDDLSPDCLGHAGLV-----------------------------YE 352

  Fly   376 DTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEG-IVPGGGTA 439
            .|..| ||....|:.....|...|::  |.::..:.:.||.|.|.|.|.:.|:::| :|||.|..
Human   353 YTLGE-EKFTFIEKCNNPRSVTLLIK--GPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAV 414

  Fly   440 LLRCIEKL-EGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVE---NQAGD-YGY 499
            .:...|.| :...:.....:|||:....||.:....:|:|:|.|....:.|::   :::|. .|.
Human   415 EVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGV 479

  Fly   500 DALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGG 562
            |...||.....|.|:.|...|.:..:...:.:|    |...:|.||.:       .||..:.|
Human   480 DLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIA----TNILLVDEIMR-------AGMSSLKG 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	124/563 (22%)
CCT6A	NP_001753.1	chap_CCT_zeta	3..530	CDD:274088	128/580 (22%)