DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and CCT2

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_012124.1	Gene:	CCT2 / 854664	SGDID:	S000001404	Length:	527	Species:	Saccharomyces cerevisiae

Alignment Length:	572	Identity:	144/572 - (25%)
Similarity:	240/572 - (41%)	Gaps:	109/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FGPEV--------RAMMLQGVDVLADAVAVTMGPKGRNVIIEQ-SWGSPKITKDGVTVAKSIELK 83
            ||.:|        |.....|...:.|.|..|:||||.:.:::. |..:..:|.||.|:.|||.|
Yeast     6 FGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPL- 69

  Fly    84 DKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKG-ANPVEIRRGVMLAVETV 147
               .|..||::.:::...::|.|||||:.|||:..:.:|..:.|.:. .:|..|..|..||....
Yeast    70 ---DNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAA 131

  Fly   148 KDNL----------KTMSRPVSTPEEIAQVA--TISANGDQAIGNLISEAMKKVGRDGVITVKDG 200
            .|.|          |||.|     |::..:|  |:|:.    |.:...:...::..:.::.:| |
Yeast   132 LDALTKAAVDNSHDKTMFR-----EDLIHIAKTTLSSK----ILSQDKDHFAELATNAILRLK-G 186

  Fly   201 KTLTDELEVIE--GMKFDRGYISPYFINSSK----------GAKVEFQDALLLLSEKKI----SS 249
            .|..:.:::|:  |.|....::...||.:.|          .||:...:..|...:.||    ..
Yeast   187 STNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFK 251

  Fly   250 VQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAI 314
            |.|.....:|..|:|:.:......|....::|.:..:|             ..|..:...||:.|
Yeast   252 VDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQL-------------IYDYPEQLFTDLGI 303

  Fly   315 ASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTS 379
            .|     .:.||   .|.|:...|...||||.|.|:.  .|.|..:.||:
Yeast   304 NS-----IEHAD---FEGVERLALVTGGEVVSTFDEP--SKCKLGECDVI--------------- 343

  Fly   380 EYEKEKLQERLARLASG-------VALLRVGGSSEVEVNEKKDRVHDALNA-TRAAVEEGIVPGG 436
              |:..|.|:.....||       ..:||  |:::..::|.:..:||||:. ::...|...|.||
Yeast   344 --EEIMLGEQPFLKFSGCKAGEACTIVLR--GATDQTLDEAERSLHDALSVLSQTTKETRTVLGG 404

  Fly   437 GTALLRCIEKLEGVETTNEDQK--LGVEIVRRALRMPCMTIAKNAGVDGAMVVAK----VENQAG 495
            |.|.: .:.|....|..|.|.|  |.||...||||.....:|.|||.|.:.:|:|    :.|...
Yeast   405 GCAEM-VMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGIS 468

  Fly   496 DYGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPK 547
            ..|.|...|...::.:.||::..|:.|..::.||..|.:|...:.::...|:
Yeast   469 TSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	144/572 (25%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	143/567 (25%)
CCT2	NP_012124.1	TCP1_beta	5..520	CDD:239452	143/570 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810