DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and CCT7

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_012424.1	Gene:	CCT7 / 853333	SGDID:	S000003647	Length:	550	Species:	Saccharomyces cerevisiae

Alignment Length:	587	Identity:	130/587 - (22%)
Similarity:	240/587 - (40%)	Gaps:	88/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VRFGPEVRAMML--QGVD----------------VLADAVAVTMGPKGRNVIIEQSWGSPKITKD 72
            :.||.:...:::  :|.|                .:.:|:..|:||.|.:::|..|.....|:.|
Yeast     1 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65

  Fly    73 GVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEI- 136
            |.|:.|.:::    .:..||.:.|::...:.|.|||||:.|:||..:.||....:.:|.:...|
Yeast    66 GATILKLLDV----VHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIM 126

  Fly   137 ---RRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVK 198
               |:.|.||||.:.:....::...|:..|:.:....:|...:.|.| .::...|:..|.|:::
Yeast   127 KGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHN-NADFFVKMCVDAVLSL- 189

  Fly   199 DGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISS--VQSIIPALELAN 261
            |...|.|:|..|:  |...|.:......:....|..|..|......||.::  :.|:...||| .
Yeast   190 DRNDLDDKLIGIK--KIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELEL-K 251

  Fly   262 AQRKPLVIIAEDIDG-----EALSTLVVNRLK----IGLQVAAVKAPGFGDNRKSTLTDMAIASG 317
            |::....:..|.::.     :|...|:..:|:    .|..:...|.| .||.......|..|...
Yeast   252 AEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP-IGDLATQFFADRNIFCA 315

  Fly   318 GIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYE 382
            |.|..||.:.|      :..:|  |.:..|..|                   ||.:...|.:.:|
Yeast   316 GRVSADDMNRV------IQAVG--GSIQSTTSD-------------------IKPEHLGTCALFE 353

  Fly   383 KEKLQERLARLASG------VALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTA-- 439
            :.::......|..|      ..||..||:.:| :.|.:..:|||:...:.|::..::..||.|
Yeast   354 EMQIGSERYNLFQGCPQAKTCTLLLRGGAEQV-IAEVERSLHDAIMIVKRALQNKLIVAGGGATE 417

  Fly   440 --LLRCIEKLEGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVE--NQAGD--YG 498
              :.:|:....  :|....|::.:....:||.:....:.:|||.|...::.|:.  :..|:  ||
Yeast   418 MEVSKCLRDYS--KTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480

  Fly   499 YDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPKED-GAPAMPGMGGMGG 562
            ........|:...|.:.:|..|...|:..|:...:|:.:.:..:|....|. .|..||..|...|
Yeast   481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRG 545

  Fly   563 MG 564
            .|
Yeast   546 RG 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	123/569 (22%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	122/564 (22%)
CCT7	NP_012424.1	TCP1_eta	9..529	CDD:239456	121/559 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810