DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60A and CCT4

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_010138.1	Gene:	CCT4 / 851412	SGDID:	S000002302	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	553	Identity:	129/553 - (23%)
Similarity:	227/553 - (41%)	Gaps:	100/553 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQ 95
            |||...:.....:|||:..::||||.:.:|:.|.|...|:.||.|:.|.:.:....    |:::.
Yeast    19 EVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLV 79

  Fly    96 DVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVST 160
            :|:...:.|||||||:..:|..|:.......::||.:|..|......|.:...|.|..|...||.
Yeast    80 EVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSL 144

  Fly   161 PEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVKD-----------------GKTLTDELE 208
            .:....|...|.:....|.:..|..:..:..|.|:.:.|                 |.|: |:.|
Yeast   145 SDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTI-DDTE 208

  Fly   209 VIEGMKFDRGYI----SPYFINSSKGAKVEFQDALLLLSEKKISSVQSII-----PALELANAQR 264
            :|:|:...:..|    .|.....:|...::||     :|..|..:..:||     ...::...:|
Yeast   209 MIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ-----ISPPKPDTENNIIVNDYRQMDKILKEER 268

  Fly   265 KPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVK 329
            ..|:.|.:.|.....:.|::                    :||.|.| |:....:.|....:::.
Yeast   269 AYLLNICKKIKKAKCNVLLI--------------------QKSILRD-AVNDLALHFLSKLNIMV 312

  Fly   330 LEDVKVSDLGQVGEVVITKDDTLLLKGKGKK---------DDVLRRANQIKDQIEDTTSEYEKEK 385
            ::|::..::            ..|.||.|.|         :|.|..|:.:::...|.:.......
Yeast   313 VKDIEREEI------------EFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTG 365

  Fly   386 LQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEE-GIVPGGGTALLRCIEKL-- 447
            ::...||....|.   :.|::.:.::|.:..:||||...|..|:| |::.|||...:....:|
Yeast   366 IRNNNARPTVSVV---IRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427

  Fly   448 -----EGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVV----AKVENQAGDYGYDALK 503
                 |||      |....:....||.:...|:|:|||::...||    :|.||...:.|....:
Yeast   428 EARSMEGV------QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRR 486

  Fly   504 GEYGNLIEKGIIDPTKVVRTAITDASG-VASLL 535
            ....|..|:.|:.|..|..:|||.||. |.|:|
Yeast   487 SGTTNTYEEHILQPVLVSTSAITLASECVKSIL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	129/553 (23%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	129/553 (23%)
CCT4	NP_010138.1	chap_CCT_delta	11..528	CDD:274083	129/553 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900