DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60A and HSP60

DIOPT Version :9

Sequence 1:	NP_511115.2	Gene:	Hsp60A / 32045	FlyBaseID:	FBgn0015245	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_013360.1	Gene:	HSP60 / 850963	SGDID:	S000004249	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	579	Identity:	328/579 - (56%)
Similarity:	436/579 - (75%)	Gaps:	13/579 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRLPVSLARSSISRQLAMRGYA--KDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQS 63
            |.|..|..:|::: |.|..|.|:  |:::||.|.||.:|:||:.||:|||.|:|||||||:|||.
Yeast     1 MLRSSVVRSRATL-RPLLRRAYSSHKELKFGVEGRASLLKGVETLAEAVAATLGPKGRNVLIEQP 64

  Fly    64 WGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKIS 128
            :|.||||||||||||||.|||||:|:||||:|:||:.|||.||||||:||||.|||..|..:.::
Yeast    65 FGPPKITKDGVTVAKSIVLKDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVA 129

  Fly   129 KGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGRDG 193
            .|.||:::|||..:|||.|.:.|....:.::|.||||||||||||||..:|.|::.||:|||::|
Yeast   130 AGCNPMDLRRGSQVAVEKVIEFLSANKKEITTSEEIAQVATISANGDSHVGKLLASAMEKVGKEG 194

  Fly   194 VITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPALE 258
            |||:::|:||.|||||.|||:||||:||||||...|.:||||:..|||||||||||:|.|:||||
Yeast   195 VITIREGRTLEDELEVTEGMRFDRGFISPYFITDPKSSKVEFEKPLLLLSEKKISSIQDILPALE 259

  Fly   259 LANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGD 323
            ::|..|:||:|||||:|||||:..::|:|:..::|.||||||||||||:|:.|:|:.:||.||.:
Yeast   260 ISNQSRRPLLIIAEDVDGEALAACILNKLRGQVKVCAVKAPGFGDNRKNTIGDIAVLTGGTVFTE 324

  Fly   324 DADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIE-DTTSEYEKEKLQ 387
            :.|| |.|...:.:||....:.:||:||::|.|.|.|:.:..|..|||..|: .||:.|||||||
Yeast   325 ELDL-KPEQCTIENLGSCDSITVTKEDTVILNGSGPKEAIQERIEQIKGSIDITTTNSYEKEKLQ 388

  Fly   388 ERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVET 452
            ||||:|:.|||::||||:|||||.|||||..||||||||||||||:|||||||::....|:.|..
Yeast   389 ERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNATRAAVEEGILPGGGTALVKASRVLDEVVV 453

  Fly   453 TNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGD---YGYDALKGEYGNLIEKGI 514
            .|.||||||:|:|:|:..|...|.:|||.:|::::.|:.::.||   .||||.|.||.:::..||
Yeast   454 DNFDQKLGVDIIRKAITRPAKQIIENAGEEGSVIIGKLIDEYGDDFAKGYDASKSEYTDMLATGI 518

  Fly   515 IDPTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMGGMGGMGGMM 573
            |||.||||:.:.|||||||||.|.|..:.:.|:   .||..|.|||  .|||.||.|||
Yeast   519 IDPFKVVRSGLVDASGVASLLATTEVAIVDAPE---PPAAAGAGGM--PGGMPGMPGMM 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60A	NP_511115.2	PTZ00114	12..549	CDD:185455	310/542 (57%)
Hsp60A	NP_511115.2	GroEL	24..544	CDD:239460	305/523 (58%)
HSP60	NP_013360.1	GroEL	25..548	CDD:239460	305/523 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343953
Domainoid	1	1.000	582	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1626
Inparanoid	1	1.050	626	1.000	Inparanoid score	I120
Isobase	1	0.950	-	0	Normalized mean entropy	S222
OMA	1	1.010	-	-		QHG61846
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm46722
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	LDO	PTHR45633
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R572
SonicParanoid	1	1.000	-	-		X1504
TreeFam	1	0.960	-	-
	16	15.740